Anti cancer Flashcards
What is tamoxifène?
antagoniste compétitif des estrogènes aux ER
(agoniste partiel avec activité intrinsèque assez faible)
Used in cancer de sein when the issue is too many estrogen receptors
What type of therapy is tamoxifène?
Hormonal therapy
We are prescribing an estrogen-like drug that will reduce the activity of estrogen receptors in the **
What type of receptors are tyrosine kinase
type A.3 recepteur transmembranaire
activite tyrosine kinase -> dimerisation
What is HER1?
EGFR (growth factor) that is induced by tyrosine kinase and leads to cell proliferation +++
What is the role of EGFR?
Causes proliferation cellularie
Often over-expressed i ncancer cells
How can we treat cancer du poumon HER1 positif?
inhibiteur de l’activité tyrosine kinase (suffixe inib )
How can we treat cancer du sein HER2 positif?
inhibition de l’activité TK -inib medication
could also target the receptor with monoclonal antibodies -mab
-inib medication?
inhibiteur de
l’activité tyrosine kinase
What type of treatment for HER2 positif?
anticorps monoclonal
+ agents cytotoxiques conventionnels
What is the problem with Agents cytotoxiques?
This is the cancer treatment that is usually used
It targets cell replicaiton generally so it can target other cells
Quelle phase du cycle cellulaire est la cible principale des agents cytotoxiques? Nommez-les.
Phase S (réplication de l’ADN)
Quel est le mécanisme d’action des agents alkylants?
Block by bidning to DNA
* Forment des ponts entre 2 bases azotées des chaînes d’ADN
ihibitaion of growth -> cell death
i) arrêt du cycle cellulaire, ii) inhibition de la croissance cellulaire et iii)
apoptos
How do Antimétabolites work?
Reduce number of available nucleic acid -> less avail for DNA synthesis
How do Anti‐topoisomérases work?
Block from opening the DNA double strand
What is the activity of Anthracyclines?
- agissent comme agents intercalants : s’insèrent entre 2 paires de bases azotées
des acides nucléiques, ce qui produit une inhibition de la réplication
