Anti-coagulent drugs Flashcards Preview

Module 103, Theme 2: Formation, composition, function and disorders of the blood. > Anti-coagulent drugs > Flashcards

Flashcards in Anti-coagulent drugs Deck (43)
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1

Warfarin

Vitamin K antagonist- therefore prevents gamma coagulation of factors 2, 7, 9, 10.

Increases extrinsic pathway- higher PT

Inhibits protein C and S

2

Target INR for warfarin in PE/DVT and AF

2.5

3

Target INR for warfarin in recurrent VTE or metal heart valves

3.5

4

Warfarin interactions

Cytochrome P450

Some enzyme inhibitors increase effects of warfarin

Some enzyme inducers inhibit warfarin

Warfarin interacts with alcohol

5

Enzymes inducers that inhibit warfarin (4)

P R A C

pigs race across the city

Rifampicin

Amiodarone

Citalopram

Phenytoin

6

Rifampicin

Enzymes inducers that inhibits warfarin

7

Amiodarone

Enzymes inducers that inhibits warfarin

8

Citalopram

Enzymes inducers that inhibit warfarin

9

Phenytoin

Enzymes inducers that inhibit warfarin

10

Enzyme inhibitors that potentiate warfarin

Carbamazepine

Azathioprine

Allopurinol

Erythromycin

Ciprofloxacin

Metronidazole

Fluconazole

11

Carbamazepine

Enzyme inhibitor that potentiates warfarin

12

Azathioprine

Enzyme inhibitor that potentiates warfarin

13

Allopurinol

Enzyme inhibitor that potentiates warfarin

14

Erythromycin

Enzyme inhibitor that potentiates warfarin

15

Ciprofloxacin

Enzyme inhibitor that potentiates warfarin

16

Metronidazole

Enzyme inhibitor that potentiates warfarin

17

Fluconazole

Enzyme inhibitor that potentiates warfarin

18

Heparin

Mucopolysaccharide that potentiates antithrombin

Irreversibly inactivates 2a and Xa

Unfractionated IV
LMW injections

19

Unfractionated heparin

Only used due to inconvenience- i.e cancer patients.

APTT monitored 1.5-2.5 x of normal

Reversed with protamine sulphate

Safe in renal failure

20

What compound partially reverses the effect of unfractionated heparin

Protamine sulphate

21

LMW heparin

Given once daily via s.c injections- according to patient's weight

Used as thromboprophylaxis for hospital in-patients

22

LMW heparin formulations

Tinzaparin

Enoxaparin

Dalteparin

23

Hirudin

Anticoagulant derived from snake venom that is used to create drug Lepirudin.

Directly inhibits 2a

24

Lepirudin

Anticoagulant drug derived from hirudin

Inhibits 2a, used as heparin alternate method.

25

Heparinoids

Heparin-like compounds, used as anticoagulant alternative to heparin.

Includes: danaparoid

26

Danaparoid

A heparinoid that is heparin-like.

27

Fondaparinux

Anticoagulant, alternative to warfarin and heparin.

Includes arixtra

28

Arixtra

A fondaparinux

Potentiates anti-thrombin and inhibits Xa.

29

NOAC

Anticoagulant drugs alternative to warfarin.

Orally available and no monitoring needed

Classes;
Dabigatran- inhibits 2a
Rivaroxaban- inhibits 10a

30

Dabigatran

Directly inhibits 2a.

Example- argatroban