Anti-depressants / Mood Stabilizers

Question 0

Lithium has (narrow/wide) therapeutic index

Answer 0

Narrow

Question 1

Drug of choice for bipolar disorder aka mania

Answer 1

Lithium carbonate or Lithium citrate

Question 2

If patient has hyponatremia, lithium intracellular levels would (increase/decrease)

Answer 2

Increase

Question 3

MAO inhibitors given with Tyramine-rich foods will result to what ADR

Answer 3

Hypertensive crisis

Question 4

What are examples of tyramine-rich foods?

Answer 4

Wine, cheese, chicken liver

Question 5

MAO B selective inhibitor

Answer 5

Selegiline

Deprenyl

Question 6

MAO B acts on what neurotransmitter

Answer 6

Dopamine only

Question 7

MAO A acts on what neurotransmitter

Answer 7

Dopamine
Norepinephrine
Serotonin

Question 8

MAO A selective inhibitor

Answer 8

Moclobemide

Question 9

MAO nonselective inhibitors

Answer 9

Phenelzine
Isocarboxazid
Tranylcypromine

Question 10

What is Deprenyl?

Answer 10

It acts like selegeline. MAO B selective inhibitor.

Question 11

Most used group of drugs for depression

Answer 11

SSRI & SNRI

Question 12

MOA of SSRI

Answer 12

Blocks serotonin reuptake therefore increasing serotonin in synapse

Question 13

MOA of SNRI

Answer 13

Blocks serotonin and norepinephrine reuptake therefore increasing their levels in the synapse

Question 14

ADR most associated with SSRI

Answer 14

Orthostatic hypotension

Question 15

ADR most associated with SNRI

Answer 15

Hypertension

Question 16

-XETINE *except yung dulo (duloxetine) and Citalopram

Answer 16

SSRI drugs

Question 17

Duloxetine

Answer 17

SNRI

Question 18

ADR seen with all of the Antidepressants

Answer 18

Sexual dysfunction (highest in MAOIs)
Weight gain

Question 19

Antidepressant categories according to MOA

Answer 19

SSRI
SNRI
MAOI
TCA
5HT Ia antagonists

Question 20

-ZODONE

Answer 20

5HT Ia antagonists

Question 21

Inhibition of 5HT Ia leads to?

Answer 21

Increase of 5HT because 5HT Ia is inhibitory in nature

Question 22

ADR most common with 5HT Ia antagonists

Answer 22

Hepatotoxicity

Question 23

MOA of TCAs

Answer 23

SNRI-like but also blocks alpha 1, muscarinic, and histamine therefore it has many ADRs

Question 24

-TRIPTYLINE and -PRAMINE

Answer 24

TCAs

Question 25

Most severe ADR with TCAs

Answer 25

Cardiotoxicity

Question 26

SSRI drugs

Answer 26

Sertraline Fluoxetine Fluvoxamine Paroxetine

Question 27

Anti-depressants also used for OCD, Anxiety disorders, and mgt of phobia

Answer 27

SSRI and SNRI

Question 28

2nd gen Antidepressants

Answer 28

Trazodone Bupropion Amoxapine Maprotiline

Question 29

3rd gen Antidepressants

Answer 29

Venlafaxine Mirtazapine Nefazodone

Question 30

Second line antidepressants that are more commonly employed as anticonvulsants

Answer 30

Valproic acid | Carbamazepine

Question 31

Valproic acid is an (inducer/inhibitor) of CYP 450

Answer 31

Inhibitor

Question 32

Carbamazepine is an (inducer/inhibitor) of CYP 450

Answer 32

Inducer