Anti-Diarrheals (week 8&9) Flashcards
(26 cards)
What are anti-diarrheal used for?
Gi Disease - infection, inflammation, maldigestion
What are the two major groups of antidiarrheals?
Specific
Nonspecific
What are two nonspecific antidiarrheal agents?
Opioids
Diphenoxylate with Atropine
What is the biggest complain of Opioids?
Constipation
What is the most effective antidiarrheal agent?
Opioids
What are the three prototypes of opioids?
Tincture of Opium
Diphenoxylate with Atropine (Lomotil)
Loperamide (Imodium)
What are the MOA of Opioids?
Activate opioid receptors in GI tract?
Why is Atropine added to Diphenoxylate?
to prevent abse and anti-cholinergic effects
What opioid was little or no potential for abuse?
Loperamide
What are the specific anti-diarrheals?
Antibiotics
What are two examples of IBD?
Crohns disease
Ulcerative Colitis
What are the charactoristics of IBS?
Crampy abdominal pain
Diarrhea
Constipation
What is IBS-M?
Irritable Bowel Syndrome Mixed (Constipation and Diarrhea)
What are the two categories of drugs for IBS?
Nonspecific
Specific
Name some Nonspecific drugs for IBS
Antispasmodics
Bulk-forming agents
Antidiarrheals
Tricyclic Antidepressants (TCA)
Name a Specific IBS drug
Alosetron (Setron - Serotonin)
What is the MOA of Alosetron?
Selective blockade of 5-HT3 receptors
What are the adverse effects of Alosetron?
Constipation
What are the drugs used to control IBD?
5-Aminosalicylates Glucocorticoids Immunosuppressants Immunomodulators Antibiotics
What is the focus of care for IBD?
Antibiotics
Anti-inflammatory
Immunosuppressants
Name a Prokinetic Agent
Metoclopramide (Reglan)
What is the use of Metoclopramide (Replan) when taken orally?
Diabetic Gastroparesis
GERD
What is the use of Metoclopramide (Replan) when given IV?
N/V
Difficult NG Placement
What is the MOA of Metoclopramide (Replan) When taken for emesis?
Blocks receptors for dopamine and serotonin in the CTZ
