Urinary Issues and Men's Health Issues (week 8&9)

Question 1

Name a Cholinergic Muscarinic Agonist

Answer 1

Bethanechol (Urecholine)

Question 2

What is Bethanechol (Urecholine) used for?

Answer 2

Urinary retention in post op, postpartum

Question 3

What is the MOA of Bethanechol (Urecholine)?

Answer 3

Activates Muscarininc receptors of the urinary tract.

Question 4

What are the adverse effects of Bethanchol (Urecholine)?

Answer 4

Hypotension
Bradycardia
Bronchoconstriction

Question 5

Before administration of Bethanechol (Urecholine), what kind of PMH do you want to be aware of?

Answer 5

Hyperthyroidism
Hypotensive or Bradycardia pt’s
Small bowel or urinary tract obstructions

Question 6

How should you administer Bethanechol (Urecholine)?

Answer 6

One hour before or after food

Nausea and vomiting will occur if taken with food

Question 7

What is the reversal agent of Bethanechol (Urecholine)?

Answer 7

Atropine

Question 8

What are the signs and symptoms of muscarinic poisoning?

Answer 8

Profuse salivation and tearing
Bronchospasms
Diarrhea
Bradycardia
Hypotension

Question 9

Name a Cholinergic M3 Antagonist

Answer 9

Oxybutynin (Ditropan XL)

Question 10

What is Oxybutynin used for?

Answer 10

Overactive bladder

Question 11

What is the MOA of Oxybutynin (Ditropan XL)?

Answer 11

Block M receptors of the urinary tract

Question 12

What are some adverse effects of Oxybutynin (Ditropan XL)?

Answer 12

Meets Beers Criteria
Constipation, blurred vision, photophobia, dry eyes, and dry mouth
Tachycardia if blended into M1 and M2 receptors

Question 13

What do you want to know before administering Oxybutynin (Ditropan XL)?

Answer 13

Urinary patterns

Question 14

If someone has Glaucoma and severely decreased gastric motility, what drug can you not give them?

Answer 14

Oxybutynin (Ditropan XL)

Question 15

What should you advise a patient to do when they are experiencing anticholinergic effects?

Answer 15

Chew gum
Wear sunglasses
Avoid hazardous activity

Question 16

What is the reversal agent to Oxybutynin (ditropan XL) ?

Answer 16

Physostigmine

Question 17

What are the two major concerns for mens health?

Answer 17

Erectile Dysfunction

Benign Prostatic Hyperplasia

Question 18

What class of drugs are used to treat ED?

Answer 18

PDE5 Inhibitors

Question 19

Name two PDE5 Inhibitors

Answer 19

Sildenafil (Viagra)

Cialis

Question 20

What is the MOA of PDE5 Inhibitors?

Answer 20

Converst cGMP to GMP

Question 21

What is the MOA of Sildenafil (Viagra)?

Answer 21

Prevents cGMP from converting to GMP

Question 22

What is taken for Pulmonary arterial HTN but can also be used for ED?

Answer 22

Revatio

Question 23

When does Sildenafil (Viagra) peak?

Answer 23

60 min on an empty stomach of 2 hours after high fat meal

Question 24

What are some adverse effects of Sildenafil (Viagra)?

Answer 24

Hypotension in men taking Nitrates
Priapism (erection lasting over 6 hours)

Sudden hearing loss
Sudden vision loss

Question 25

When you should you take Viagra?

Answer 25

Once daily one hour before sexual activity

Question 26

What drug is given daily regardless of sexual activity?

Answer 26

Tadelafil (Cialis)

Question 27

What are the two approaches of BPH?

Answer 27

Mechanical (Overgrowth of epithelial cells) | Dynamic (Overgrowth of smooth muscle cells)

Question 28

Name a 5 -Alpha-Reductase Inhibitor

Answer 28

Finasteride (Proscar)

Question 29

What is Finasteride (Proscar) used for?

Answer 29

Enlarged prostate

Question 30

What is the MOA of Finasteride (Proscar)?

Answer 30

Promotes regression of prostate epithelial tissue

Question 31

Who should not take e Finasteride (Proscar)?

Answer 31

Pregnant women or those who may become pregnant

Question 32

If the PSA is constantly increasing, what does this indicate?

Answer 32

Prostate cancer

Question 33

Name an Alpha1-Adrenergic Antagonist

Answer 33

Tamsulosin (Flomax)

Question 34

What is Tamsulosin (Flomax) used for?

Answer 34

Mild prostatic enlargement but still having issues urinating

Question 35

What is the MOA of Tamsulosin (Flomax)?

Answer 35

Selective blockage of Alpha1 receptors relaxes smooth muscle in bladder neck and prostate

Question 36

What drug should be taken life long?

Answer 36

Tamsulosin (Flomax)