Anti Dylipidemic 2

Question 1

What side effect is associated with fibrates?

Answer 1

Increased risk of gall stones

Question 2

What can gemfibrozil cause?

Answer 2

Myopathy

Question 3

What are Bile Acid Binding Agents (BABA)?

Answer 3

Cholestyramine, Cholestipol, Cholesevalam

Question 4

What is the mechanism of action (MOA) of BABA?

Answer 4

Interrupts enterohepatic cycling of bile acids

Question 5

What substances do bile acids carry from the gut?

Answer 5

Substances released into blood and secreted in bile

Question 6

What is the drug of choice (DOC) in children and pregnancy?

Answer 6

Bile Acid Binding Agents (BABA)

Question 7

Which BABA is available as a tablet?

Answer 7

Cholesevalam

Question 8

What is the maximum effect of Niacin (Vitamin B3)?

Answer 8

Maximum HDL-Cholesterol increasing potential

Question 9

Which drug decreases Lipoprotein A?

Answer 9

Niacin (Vitamin B3)

Question 10

What are the compliance-limiting adverse effects of Niacin?

Answer 10

Flushing and itching

Question 11

What can prevent flushing and itching caused by Niacin?

Answer 11

Aspirin or Laropiprant

Question 12

What is the role of Laropiprant?

Answer 12

Blocks action of PGD2 to prevent flushing/itching

Question 13

What are other side effects of Niacin?

Answer 13

• Hyperuricemia
• Hepatotoxicity
• Insulin resistance

Question 14

Fill in the blank: BABA interrupts _______ cycle.

Answer 14

enterohepatic

Question 15

True or False: Cholestyramine is easily palatable.

Answer 15

False

Question 16

What needs to be done with Cholestyramine and Cholestipol before consumption?

Answer 16

Dissolved in water overnight

Question 17

What is the role of PCSK-9 in relation to LDL receptors?

Answer 17

PCSK-9 binds to LDL receptors and takes them to lysosomes, resulting in their breakdown.

Question 18

How do PCSK-9 inhibitors affect LDL receptors?

Answer 18

They prevent the breakdown of LDL receptors, allowing more LDL receptors to take up LDL-cholesterol from blood.

Question 19

What are some examples of PCSK-9 inhibitors?

Answer 19

• Inclisiran
• Alirocumab
• Evolocumab

Question 20

What is the function of MTP (Microsomal Triglyceride Transport Protein)?

Answer 20

MTP packs triglycerides in VLDL.

Question 21

What drug inhibits MTP?

Answer 21

Lomitapide

Question 22

What is Mipomersen and its action?

Answer 22

Mipomersen is an antisense oligonucleotide against Apo B100, decreasing all Apo B100 containing lipids.

Question 23

What is the function of CETP (Cholesterol Ester Triglyceride Transport Protein)?

Answer 23

CETP facilitates the exchange of cholesterol ester of HDL with triglyceride in VLDL and LDL.

Question 24

What is the effect of CETP inhibitors on HDL cholesterol?

Answer 24

CETP inhibitors increase HDL-cholesterol.

Question 25

What is an example of a CETP inhibitor?

Answer 25

ANACETRAPIB

Question 26

What does Evinacumab target?

Answer 26

Evinacumab is a monoclonal antibody against ANGPTL3 (Angiopoietin Like Protein 3).

Question 27

What is the role of ANGPTL3 in lipid metabolism?

Answer 27

ANGPTL3 inhibits LPL (Lipoprotein Lipase) and Endothelial lipase (EL).

Question 28

What is the effect of Evinacumab on LDL, VLDL, TG, and HDL?

Answer 28

Evinacumab decreases LDL, VLDL, TG and increases HDL.

Question 29

True or False: Evinacumab acts independently of LDL-receptor density.

Answer 29

True