Anti-epileptic, anti Parkinson's, and anti Alzheimer drugs

Question 1

True or false: it is abnormal for children to have seizures w/o having epilepsy. Explain your reasoning.

Answer 1

F: children can have fever induced seizures

Question 2

-barbituates
-hydantoins
-Iminostilbenes
-2nd/3rd gen antiepileptics
These are ____ drugs

Answer 2

AEDs

Question 3

AED therapies require:

Answer 3

serum drug testing

Question 4

AED drugs carry a black box warning for

Answer 4

suicidality

Question 5

Barbituates for epilepsy (phenobarbitol and primidone) have a _____ half life and carry what contraindications

Answer 5

long
-contra: heart meds, liver/kidney disease, birth control

Question 6

Restlessness is a symptom of barbituates: t/f

Answer 6

T

Question 7

Hydantoins (phenytoins) are given __ and compete with _____ ______ drugs like ______.

Answer 7

IV, protein bound, warfarin

Question 8

Phenytoin cannot be taken with

Answer 8

-other protein bound drugs

Question 9

What lab would you assess if giving hydantoins? How would you give it IV?

Answer 9

-monitor albumin levels
-slow IV into large vein w large needle, flushed before/after

Question 10

Phenytoin side effects (hint: werewolf)

Answer 10

-bad teeth
-acne
-increased fat tissue in face
-hirsutism (hair growth

Question 11

Iminostilbenes drugs include carbamazepine and oxcarbazepine–how are the two different?

Answer 11

Carb: hepatic enxyme inducer–can build tolerance
Ox: is not a HEI

Question 12

A pt says they are taking CARBAMAZEPINE for absent seizures with a glass of gfruit juice in the AM. Your first priorities are to…

Answer 12

-tell them to STOP immedieatly that is bad–no gfruit and only for partial/general seizure

Question 13

Gabapentin is used for treatment of ______ seizures and __________. It carries ___ symptoms

Answer 13

partial, neuropathy.
-GI

Question 14

LyriCa MOA and use

Answer 14

MOA: binds to Ca channels, slows shit down
-“add on” therapy for seizure, neuropathy, fibromyalgia

Question 15

What seizure meds are protein bound?

Answer 15

-hydantoins
-valproic acid

Question 16

A pt says they take their valproic with a can of diet coke every morning. What is the pts diagnosis? what is your response?

Answer 16

-BPD, generalized or partial seizure
-dont do that

Question 17

Parkinson’s symptoms (TRAP)

Answer 17

Tremor
Rigidity
Akinesia (slow movement)
Postural instability

Question 18

Drugs for parkinson’s increase ________ and reduce the effects of_______

Answer 18

dopamine, Ach (acetylcholine).

Question 19

Selegine and rasagiline treat ______. What is their class?

Answer 19

Parkinson’s
-MOAIs: increase dopamine

Question 20

MAOIs, when taken with cheese or wine, can cause…

Answer 20

hypertensive crisis

Question 21

Which dopamine replacement drugs cross the BBB? Which don’t? What are these used for?

Answer 21

doesn’t cross: levadopa
crosses: carbidopa
Parkinson’s

Question 22

Patients should eat lots of protein with “dopa” drugs: t/f

Answer 22

F! protein can slow drug’s effects

Question 23

Benztropine (an _________) is used to treat _______ because they block the effect of ___.

Answer 23

anticholinergic, Parkinson’s, Ach (acetylcholine).

Question 24

Aricept and Namenda treat ______. Name their MOAs and side effects

Answer 24

Aricept–Ach inhibitor
-diarrhea, headache
Namenda–NMDA antagonist
-fatigue