Anti Inflammatory and Gout Flashcards
Aspirin MOA, dose, use, side effects
-COX blockers (lol)
-analgesic, anti-inflamm, antipyretic, AND antiplatelet
-(81 - 324 mg) treats MI, headache, arthritis, lupus…
-side effects: GI bleed, tinnitus, Reye’s (in peds)
The only COX-2 inhibiting NSAID still on the market is…
celecoxib (celebrex)
ibuprofen, ketoprofen, and naproxen: MOA, use, side effects
-nonspecific COX inhibitors (propionic acid drug)
-analgesic, anti-inflammatory, antipyretic: for many things incl; headache, arthritis, cramps, gout, ankylosing spondylitis
-side effects: GI bleed/upset/ulcer, renal function
What labs might one check before giving an NSAID?
Kidney/renal function:
-Creatinine (0.6 - 1.3)
-BUN (7-20)
Ketorolac (toradol) is primarly used as a powerful ______, and can only be given for (how long?)
Analgesic, 5 days (severe side effects on kidney, GI)
Why are most COX-2 inhibitors (rofecoxib, valdecoxib) no longer on the market?
It was found that they increased risk for CV events (MI, stroke, death)
ibuprofen, ketoprofen, and naproxen rec. doses
-ibuprofen: 3200mg/day (800 QID)
-naproxen: 1000mg/day (500 BID)
-ketoprofen: 800 mg/day (200 QID)
T/F: Corticosteroids mimic hormones already made in the body
True! (glucocorticoids, mineralocorticoids, sex hormones)
Corticosteroid MOA
Modifying enzyme activity–suppress immune response + therefore, inflammation
Common corticosteroids
dexamethasone, methylprednisone (IV), prednisone (PO)
Corticosteroid side effects
mood changes, hyperglycemia, osteoporosis, ulcers, bloating, muscle weakness
COX-2 inhibitors became briefly popular because, unlike other NSAIDs, they did not have what side effect?
GI upset
1st line gout therapy?
NSAIDS
Allopurinol MOA, use, side effects
-inhibits xanthine oxidase (prevents uric acid production), treats gout
-side effects: anemia, skin stuff; exfoliative dermatitis/agranulocytosis
febuxostat MOA, use, side effects
-selectively inhibits xanthine oxidase (prevents uric acid production), treats gout
-side effects: CV events
