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Flashcards in Anti Epileptic Drugs Deck (64)
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1

Absorption of carbamazepine is ______ by food

accelerated

2

carbamazepine is metabolized by ______, _____, _______

3A4/ 1A2/ 2C8

3

name four drugs that inhibit the metabolism of carbamazepine

ketoconazole/ fluconazole/ erythromycin/ diltiazem

4

what is the major metabolite of carbamazepine? Is it active or inactive?

10, 11 epoxide/ active

5

Carbamazepine is an ___. This process begins within ________ and takes ____ to complete.

auto-inducer/ 3-5/ 21-28

6

the auto-induction of carbamazepine reverses _____ when the drug is discontinued

rapidly

7

what is the half life of carbamazepine?

20-50 hours after the first dose, 10-25 hours after completion of the auto-induction phase

8

what is the time to peak for carbamazepine?

2-24 hours

9

what is a therapeutic range for carbamazepine levels in the blood?

4-14 mcg/ml

10

Explain how to dose carbamazepine

Begin with 200 mg twice daily with meals. Increase in 200 mg increments every other day. Final range usually 600-1600 mg/day, but some patients require 2,000-3,000 mg/day.

11

read this list of carbamazepine side effects

cognitive effects, anemia, agranulocytosis, leukopenia, moderate weight gain, overflow incontinence, GI upset, risk of bone disorders, SJS, TEN, partial or complete heart block

12

you should discontinue carbamazepine if ANC is less than

1,000

13

Is carbamazepine one of our 6 decreased efficacy of OCP drugs?

yes

14

for what indication is clonazepam a best evidence drug?

myoclonic seizures

15

clonazepam is 2nd line treatment for ___

absence seizures

16

what is the brand name for carbamazepine?

tegretol

17

name two side effects of clonazepam

cognitive effects/ urge incontinence

18

name two side effects of diazepam

cognitive effects/ urge incontinence

19

how do you dose diazepam for status epilepticus?

0.2 mg/kg at 5 mg/min

20

diazepam is _____ lipophilic than lorazepam, and has a ____ duration of action

more/ shorter

21

what is the brand name of eslicarbazepine?

Stedesa

22

how does eslicarbazepine work?

blockade of fast-acting, voltage-gated sodium channels. It has a greater affinity for the inactive state of sodium channels rather than the resting state, which may make it more selective for rapidly firing neurons

23

what is eslicarbazepine used for?

adjunct therapy in patients whose seizures are uncontrollable

24

what is the brand name for ethosuximide?

zarotin

25

what is ethosuximide used for?

absence seizures

26

are the following adverse drug effects of ethosuximide dose dependent or idiosyncratic? aplastic anemia, granulocytopenia, hepatotoxicity

idiosyncratic

27

read this about ethosuximide side effects

SJS, Lupus-like reaction, and rash, as well as aplastic anemia, granulocytopenia, and hepatotoxicity are all idiosyncratic side effects of ethosuximide

28

name two chronic side effects of ethosuximide

behavioral changes, parkinsonian movements

29

what is the brand name of ezogabine?

potiga

30

what is the mechanism of ezogabine?

stabilizes K+ channels in the open position by an unknown mechanism. Augments GABA-mediated currents