Flashcards in Anti Epileptic Drugs Deck (64)
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1
Absorption of carbamazepine is ______ by food
accelerated
2
carbamazepine is metabolized by ______, _____, _______
3A4/ 1A2/ 2C8
3
name four drugs that inhibit the metabolism of carbamazepine
ketoconazole/ fluconazole/ erythromycin/ diltiazem
4
what is the major metabolite of carbamazepine? Is it active or inactive?
10, 11 epoxide/ active
5
Carbamazepine is an ___. This process begins within ________ and takes ____ to complete.
auto-inducer/ 3-5/ 21-28
6
the auto-induction of carbamazepine reverses _____ when the drug is discontinued
rapidly
7
what is the half life of carbamazepine?
20-50 hours after the first dose, 10-25 hours after completion of the auto-induction phase
8
what is the time to peak for carbamazepine?
2-24 hours
9
what is a therapeutic range for carbamazepine levels in the blood?
4-14 mcg/ml
10
Explain how to dose carbamazepine
Begin with 200 mg twice daily with meals. Increase in 200 mg increments every other day. Final range usually 600-1600 mg/day, but some patients require 2,000-3,000 mg/day.
11
read this list of carbamazepine side effects
cognitive effects, anemia, agranulocytosis, leukopenia, moderate weight gain, overflow incontinence, GI upset, risk of bone disorders, SJS, TEN, partial or complete heart block
12
you should discontinue carbamazepine if ANC is less than
1,000
13
Is carbamazepine one of our 6 decreased efficacy of OCP drugs?
yes
14
for what indication is clonazepam a best evidence drug?
myoclonic seizures
15
clonazepam is 2nd line treatment for ___
absence seizures
16
what is the brand name for carbamazepine?
tegretol
17
name two side effects of clonazepam
cognitive effects/ urge incontinence
18
name two side effects of diazepam
cognitive effects/ urge incontinence
19
how do you dose diazepam for status epilepticus?
0.2 mg/kg at 5 mg/min
20
diazepam is _____ lipophilic than lorazepam, and has a ____ duration of action
more/ shorter
21
what is the brand name of eslicarbazepine?
Stedesa
22
how does eslicarbazepine work?
blockade of fast-acting, voltage-gated sodium channels. It has a greater affinity for the inactive state of sodium channels rather than the resting state, which may make it more selective for rapidly firing neurons
23
what is eslicarbazepine used for?
adjunct therapy in patients whose seizures are uncontrollable
24
what is the brand name for ethosuximide?
zarotin
25
what is ethosuximide used for?
absence seizures
26
are the following adverse drug effects of ethosuximide dose dependent or idiosyncratic? aplastic anemia, granulocytopenia, hepatotoxicity
idiosyncratic
27
read this about ethosuximide side effects
SJS, Lupus-like reaction, and rash, as well as aplastic anemia, granulocytopenia, and hepatotoxicity are all idiosyncratic side effects of ethosuximide
28
name two chronic side effects of ethosuximide
behavioral changes, parkinsonian movements
29
what is the brand name of ezogabine?
potiga
30
