Anti-epileptic Drugs Flashcards Preview

SB_Medication Side Effects (Pediatrics Royal College 2018) > Anti-epileptic Drugs > Flashcards

Flashcards in Anti-epileptic Drugs Deck (23)
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1

What are the SE of acetazolamide?

Nuisance:
1. dizziness
2. polyuria
3. electrolyte imbalance
Serious: SJS

2

What are the SE of benzodiazepines?

Nuisance:
1. dose-related neurotoxicity (drowsiness, sedation, ataxia)
2. hyperactivity
3. drooling
4. increased secretions
Serious: apnea

3

What are the SE of bromide?

Nuisance:
1. irritability
2. spurious hyperchloremia (falsely high chloride owing to bromide)
Serious:
1. psychosis
2. rash
3. toxicity developing slowly owing to the very long half-life

4

What are the SE of carbamazepine?

Nuisance:
1. tics
2. transient leukopenia
3. hyponatremia
4. weight gain
5. nausea
6. dizziness
Serious:
1. SJS
2. agranulocytosis
3. aplastic anemia
4. liver toxicity

5

What are the SE ezogabine?

Nuisance:
1. dizziness
2. somnolence tremor
3. abnormal coordination
4. disturbance in attention
5. memory impairment
6. blurred vision
7. gait disturbance
8. dysarthria
Serious:
1. blue discoloration of the skin and retinal pigmentation that requires close ophthalmologic monitoring in follow up
2. urinary retention

6

What are the SE of felbamate?

Nuisance:
1. anorexia
2. vomiting
3. insomnia
4. hyperactivity
5. dizziness
Serious:
1. major risks for liver and hematologic toxicity requiring close monitoring (1 in 500 in children >2 yr with complex neurological disorders)

7

What are the SE of gabapentin?

In children:
1. Acute onset of aggression
2. hyperactivity
In adults:
1. euphoria and behavioral disinhibition
2. weight gain

8

What are the SE of lacosamide?

Nuisance:
1. diplopia
2. headache
3. dizziness
4. nausea
Serious:
1. possibly cardiac arrhythmias (if predisposed)

9

What are the SE of lamotrigine?

Nuisance: CNS side effects: headache, ataxia, dizziness, tremor, but usually less than other AEDs
Serious: Stevens-Johnson syndrome, rarely liver toxicity

10

What are the SE of levetiracetam?

CNS adverse events: somnolence, asthenia, dizziness, but usually less than other AEDs
In children: behavioral symptoms are common
In adults: depressive mood

11

What are the SE of oxcarbazepine?

1. Somnolence
2. headache
3. dizziness
4. nausea
5. apathy
6. rash
7. hypertrichosis
8. gingival hypertrophy
9. hyponatremia

12

What are the SE of perampanel?

1. dizziness
2. somnolence
3. fatigue
4. irritability
5. falls
6. nausea
7. weight gain
8. vertigo
9. ataxia
10. gait disturbance
11. balance disorder

13

What are the SE of phenobarbital and other barbiturates?

Nuisance:
1. neurotoxicity
2. insomnia
3. hyperactivity
4. signs of distractibility
5. fluctuation of mood
6. aggressive outbursts
Serious:
1. liver toxicity
2. SJS

14

What are the SE of phenytoin and other hydantoins?

Nuisance:
1. gingival hyperplasia
2. coarsening of the facies
3. hirsutism
4. cerebellovestibular symptoms (nystagmus and ataxia)
Serious:
1. SJS
2. liver toxicity

15

What are the SE of pregabalin?

Nuisance:
1. dizziness
2. peripheral edema
4. blurred vision
5. weight gain
6. thrombocytopenia
Serious:
1. hypersensitivity reactions
2. rhabdomyolysis

16

What are the SE of primidone?

Nuisance:
1. CNS toxicity (dizziness, slurred speech, giddiness, drowsiness, depression)
Serious:
1. liver toxicity
2. SJS

17

What are the SE of rufinamide?

Nuisance:
1. somnolence
2. vomiting
Serious: contraindicated in familial short QT interval

18

What are the SE of succinimides?

Nuisance:
1. nausea
2. abdominal discomfort
3. anorexia
4. hiccups
Serious:
1. SJS
2. drug-induced lupus

19

What are the SE of tiagabine?

Nuisance:
1. dizziness
2. somnolence
3. asthenia
4. headache
5. tremor
6. precipitation of absence or myoclonic seizures
Serious:
1. precipitation of nonconvulsive status epilepticus

20

What are the SE of topiramate?

Nuisance:
1. cognitive dysfunction
2. weight loss
3. renal calculi
4. hypohidrosis
5. fever
Serious: precipitation of glaucoma

21

What are the SE of valproic acid?

Nuisance:
1. weight gain
2. hyperammonemia tremor
3. alopecia
4. menstrual irregularities
Serious: hepatic and pancreatic toxicity

22

What are the SE of vigabatrin?

Nuisance: hyperactivity
Serious:
1. irreversible visual field deficits
2. retinopathy that requires frequent ophthalmologic evaluations and follow up

23

What are the SE of zonisamide?

1. Fatigue
2. dizziness
3. anorexia
4. psychomotor slowing
5. ataxia
6. rarely hallucinations
7. hypohidrosis
8. fever