Anti-Fungal Pharm Flashcards
(29 cards)
What is the MOA of Amphotericin B?
Forms complex with ergosterol to destroy fungal membranes
What is the MOA of Flucytosine?
Is converted to 5-dUMP and 5-UTP in the cell which inhibit DNA and RNA synthesis, respectively
What is the MOA of the Azoles?
Inhibit fungal CYP450 enzymes
What is the MOA of the Echinocandins?
Inhibit Glucan synthase
What is the suffix of the drugs in the Echinocandin class?
-Fungin
How is resistance created against Amphotericin B?
Ergosterol alteration in the fungus
How is resistance created against Flucytosine?
Altered drug metabolism
How is resistance created against Azoles?
Upregulation of fungal CYP450 enzymes
How is resistance created against Echinocandins?
Point mutations in Glucan synthase
Which Anti-fungal drugs can cross into the CSF?
Amphotericin B
Flucytosine
Fluconazole
Which drug is 1st choice for C. Neoformans?
Flucytosine
Which drug is 1st choice for Cryptococcal meningitis?
Fluconazole
Which drug is 1st choice for Aspergillus?
Voriconazole
Which drug is used for Aspergillus if pts don’t respond to the other therapies?
Caspofungin
Which drug is used to Tx dematologic fungal infections?
Ketoconazole
Which drug is used for Mucocutaneous candidiasis?
Fluconazole
What fungi is Amphotericin B used for?
Candida, C. Neoformans, Histoplasma, Blastomyces, coccidioides, Aspergillus, Mucormycosis
What fungi is Itraconazole used for?
Histoplasma, Blastomyces, Sporothrix, Dermatophytes, Onychomycosis
What fungi is Posaconazole used for?
Mucormycosis, Candida, Aspergillus
What is Micafungin used for?
Mucocutaneous candidiasis, candidemia
What is Anidulfungin used for?
Esophageal and invasive candidiasis
Which drugs can be used for prophylactic Tx for bone marrow transplants or AIDs pts?
Fluconazole
Micafungin
Which drug interacts with Rifamycin to decrease the drugs efficacy?
Itraconazole
Which drug decreases the efficacy of statins, cyclopsorines, and tacrolimus?
Voriconazole
