Anti-Fungals

Question 1

Amphoteracin B MOA

Answer 1

Binds ergosterol

Tears holes in membrane allowing electrolytes to leak out

Question 2

Amphoteracin B use

Answer 2

Serious systemic mycoses

Question 3

DOA for diaper rash and vaginal candidiasis

Answer 3

Nystatin

Question 4

Nystatin MOA

Answer 4

Binds ergosterol

Topical Amphoteracin B

Question 5

Tx for oral thrush

Answer 5

Nystatin swish and swallow

Question 6

–Azole MOA`

Answer 6

Inhibits ergosterol synthesis

inh. P-450 ensyme that converts lanosterol to ergosterol

Question 7

–Azole use

Answer 7

local less severe mycoses

Question 8

Topical –azoles

Answer 8

clotrimazole and miconazole

Question 9

Itraconazole use

Answer 9

Tx blasto, cocci, histo

dimorphic

Question 10

Flucytosine MOA

Answer 10

Inhibits DNA and RNA synthesis

conversion to 5FU by cytosine deaminase

Question 11

Major use for flucytosine

Answer 11

cocci meningitis with amphoteracin B

Question 12

–Azole toxicity

Answer 12

Testosterone inh.

Liver dys.

Question 13

Flucytosine toxicity

Answer 13

bone marrow suppression

Question 14

Caspo/micafungin MOA

Answer 14

Inh. cell wall synthesis –> inh. ß-glucan synth

Question 15

Caspo/micafungin use

Answer 15

invasive Aspergillus and Candida

Question 16

Caspo/micafungin toxicity

Answer 16

GI upset

Flushing (histamine release)

Question 17

Terbinafine MOA

Answer 17

inh. fungal enzyme squalene epoxidase

Question 18

Terbinafine use

Answer 18

dermatophytes

especially onychomycosis–nails

Question 19

terbinafine tox

Answer 19

abn. LFTs

visual disturbance

Question 20

Griseofulvin MOA

Answer 20

Interferes with microtubule fxn –> disrupts mitosis

Question 21

where does griseofulvin deposit

Answer 21

keratin containing tissue (nails)

Question 22

Griseofulvin use

Answer 22

oral tx of superficial infxns

dermatophytes

Question 23

Griseofulvin toxicity

Answer 23

teratogenic
carcinogenic
confusion
HA
activate P450 --> inc. warfarin metabolism