Anti Hypertensives Flashcards Preview

Pharm Quiz 7 > Anti Hypertensives > Flashcards

Flashcards in Anti Hypertensives Deck (28)
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1

Diuretics

Thiazides (Distal Tubule)
Loops (Loop of Henle)
Potassium-sparing (Collecting Duct)
Carbonic Anhydrase Inhibitors (Proximal Tubule)

2

RAAS (renin-angiotensin-aldosterone system)

ACE-Inhibitors
ARBs (Angiotensin Receptor Blockers)
DRI (Direct Renin Inhibitor)
Aldosterone Receptor Agonists

3

Sympathetic agents

Beta Blockers
Alpha Agonists

4

Direct Vasodilators

Ca-Channel Blockers
Hydralazine

5

Thiazides - Distal Tubule

Chlorthalidone
Hydrochlorothiazide (Sulfonamide - sulfa allergies*)
Indapamide
Metolazone

6

Hydrochlorothiazide Drug Interactions

DECREASES
anticoagulants
insulins
sulfonylureas

INCREASES
loop diuretics
digoxin
lithium

7

Loop Diuretics - Loop of Henle

Furosemide (Lasix)
Bumetanide
Torsemide

8

Furosemide (Lasix) and Torsemide ADRs

ELECTROLYTE Imbalance
HYPO kalemia, natremia, magnesemia

*Ototoxicity*

Increase LDL, Decrease HDL

9

Butemide ADRs

Muscle Cramps
Dizziness
Headache

Nausea
Encephalopathy

10

Potassium-Sparing Diuretics

*Collecting Duct*

Triamterine
Amiloride
Spironolactone


Eplenerone

11

Potassium-Sparing ADRs

Hyperkalemia
N/V
Diarrhea

12

3 ACE Inhibitors

Captopril
Lisinopril
Enalapril

13

ACE Inhibitor ADRs

Dry Cough
Hyperkalemia
Decreased Renal Function

*Angioedema*

14

3 ARBs (Angiotensin Receptor Blockers)

Losartan
Valsartan
Eprosartan

15

ARB ADRs

Hyperkalemia
*Rhabdomyelosis*

16

3 Direct Renin Inhibitors

Aliskerin

17

3 Direct Renin Inhibitors

Aliskerin
Aliskerin / HCTZ
Aliskerin / Valsartan

18

DRI ADRs

Hyperkalemia
Renal Impairment
Angioedema

19

Aldosterone Antagonists

Aldactone or Aldactazide

with K-Sparing

Spironolactone (K Sparing)
Eplenerone (K Sparing)

20

Aldosterone Antagonist ADRs

Hyperkalemia
Erectile Dysfunction
**Gynecomastia**

21

2 Groups of Calcium Channel Blockers

1. Diltiazem (Cardizem) and Verapamil (Calan) - HEART

2. Dihydropyridines - ARTERIOLES
Amlodipine
Nifedipine
Felodipine

22

Cardizem / Verapamil ADRs

Hypotension
Dizziness
Nausea

*Heart Failure*

23

Dihydropiridine ADRs
Amlodipine
Nifedipine
Felodipine

Edema
Hypotension
Flushing

24

Beta Blockers

Propanolol

SELECTIVE 2ND GEN
Atenolol
Metropolol

NONSELECTIVE 3RD GEN
Carvedilol
Labetalol

25

Beta Blocker ADRs

Bradycardia
Erectile Dysfunction
Fatigue

26

Beta Blocker OD Symptoms

Bradycardia
Hypotension
Seizures
Coma
Arrhythmia
Respiratory depression

27

2 Alpha Agonists

Clonidine
Methyldopa

28

Alpha Agonist ADRs

Dry Mouth
Sedation
Erectile Dysfunction
Weakness