Anti Hypertensives

Question 1

Diuretics

Answer 1

Thiazides (Distal Tubule)
Loops (Loop of Henle)
Potassium-sparing (Collecting Duct)
Carbonic Anhydrase Inhibitors (Proximal Tubule)

Question 2

RAAS (renin-angiotensin-aldosterone system)

Answer 2

ACE-Inhibitors
ARBs (Angiotensin Receptor Blockers)
DRI (Direct Renin Inhibitor)
Aldosterone Receptor Agonists

Question 3

Sympathetic agents

Answer 3

Beta Blockers

Alpha Agonists

Question 4

Direct Vasodilators

Answer 4

Ca-Channel Blockers

Hydralazine

Question 5

Thiazides - Distal Tubule

Answer 5

Chlorthalidone
Hydrochlorothiazide (Sulfonamide - sulfa allergies*)
Indapamide
Metolazone

Question 6

Hydrochlorothiazide Drug Interactions

Answer 6

DECREASES
anticoagulants
insulins
sulfonylureas

INCREASES
loop diuretics
digoxin
lithium

Question 7

Loop Diuretics - Loop of Henle

Answer 7

Furosemide (Lasix)
Bumetanide
Torsemide

Question 8

Furosemide (Lasix) and Torsemide ADRs

Answer 8

ELECTROLYTE Imbalance
HYPO kalemia, natremia, magnesemia

Ototoxicity

Increase LDL, Decrease HDL

Question 9

Butemide ADRs

Answer 9

Muscle Cramps
Dizziness
Headache

Nausea
Encephalopathy

Question 10

Potassium-Sparing Diuretics

Collecting Duct

Answer 10

Triamterine
Amiloride
Spironolactone

Eplenerone

Question 11

Potassium-Sparing ADRs

Answer 11

Hyperkalemia
N/V
Diarrhea

Question 12

3 ACE Inhibitors

Answer 12

Captopril
Lisinopril
Enalapril

Question 13

ACE Inhibitor ADRs

Answer 13

Dry Cough
Hyperkalemia
Decreased Renal Function

Angioedema

Question 14

3 ARBs (Angiotensin Receptor Blockers)

Answer 14

Losartan
Valsartan
Eprosartan

Question 15

ARB ADRs

Answer 15

Hyperkalemia

Rhabdomyelosis

Question 16

3 Direct Renin Inhibitors

Answer 16

Aliskerin

Question 17

3 Direct Renin Inhibitors

Answer 17

Aliskerin
Aliskerin / HCTZ
Aliskerin / Valsartan

Question 18

DRI ADRs

Answer 18

Hyperkalemia
Renal Impairment
Angioedema

Question 19

Aldosterone Antagonists

Answer 19

Aldactone or Aldactazide

with K-Sparing

Spironolactone (K Sparing)
Eplenerone (K Sparing)

Question 20

Aldosterone Antagonist ADRs

Answer 20

Hyperkalemia
Erectile Dysfunction
Gynecomastia

Question 21

2 Groups of Calcium Channel Blockers

Answer 21

1. Diltiazem (Cardizem) and Verapamil (Calan) - HEART
2. Dihydropyridines - ARTERIOLES
   Amlodipine
   Nifedipine
   Felodipine

Question 22

Cardizem / Verapamil ADRs

Answer 22

Hypotension
Dizziness
Nausea

Heart Failure

Question 23

Dihydropiridine ADRs
Amlodipine
Nifedipine
Felodipine

Answer 23

Edema
Hypotension
Flushing

Question 24

Beta Blockers

Answer 24

Propanolol

SELECTIVE 2ND GEN
Atenolol
Metropolol

NONSELECTIVE 3RD GEN
Carvedilol
Labetalol

Question 25

Beta Blocker ADRs

Answer 25

Bradycardia Erectile Dysfunction Fatigue

Question 26

Beta Blocker OD Symptoms

Answer 26

``` Bradycardia Hypotension Seizures Coma Arrhythmia Respiratory depression ```

Question 27

2 Alpha Agonists

Answer 27

Clonidine | Methyldopa

Question 28

Alpha Agonist ADRs

Answer 28

Dry Mouth Sedation Erectile Dysfunction Weakness