Anti-inflammaotry Drugs

Question 1

What are anti inflammatory drugs

Answer 1

Inflammation of some kind associated with all pathogens and non-pathogenic diseases

Question 2

Symptoms of inflammation

Answer 2

Swelling and redness
Heat and fever
Pain

Question 3

What does acute inflammation secrete

Answer 3

TNF-A, IL-1 IL-6

Question 4

Name soem anti-inflammatory drugs

Answer 4

Antihistamines
Corticosteroids
NSAIDs

Question 5

What is histamine

Answer 5

Nitrogenous compound

Question 6

What is the main histamine receptors

Answer 6

H1

Question 7

What is h1 present on

Answer 7

Immune cells such as macrophages, nuetrophils

Question 8

What does histamine binding to hq contribute to

Answer 8

Vasodilation
Sensory nerve ending/pain/itching
Increase capillary permeability

Question 9

What do anti-inflammatory anti-histamines target

Answer 9

Histamine - h1 receptors
H1 receptor agonist and reverse agonists

Question 10

What are the uses of antiinflammatoreis

Answer 10

Allergies, itching, swelling

Question 11

What are the main classes of corticosteroids

Answer 11

Mineralcoricoids
Glucocorticoids

Question 12

What are the activities corticosteroids so to reduce inflammation

Answer 12

Reduce cytokine production
Reduce prostaglandin production
Very powerful immunosuppression

Question 13

What is transgression of corticosteroids

Answer 13

Bound glucocorticoid on receptor
Gr moves into nucleus
Interferes with other TF - decrease pro inflammatory proteins
Binds to NF-KB element and GR cells switch it off
Reduces mRNA production

Question 14

What is transactivaton of corticosteroids

Answer 14

GR attatched to receptor moves into nucleus
Regulates gene expression
Increases anti-inflammatory protein
GR attatches to glucocorticoids response element
Leads to upregulation of I-KB
InhibitsNF-KB

Question 15

What is NSADS mode of action against

Answer 15

Prostaglandins

Question 16

What are NSAIDS defined by

Answer 16

Inhibition of one or more steps in the metabolism of arachnoid acid AA

Question 17

What is acute inflammation

Answer 17

Primary response to microbial, chemical or physical injury

Question 18

What is chronic inflammation

Answer 18

Follows acute inflammation
If offending material is not destroyed then continual of a macrophages and fibroblasts occurs

Question 19

Complications of antihistamines

Answer 19

First gen antihistamines - cause drowsiness and be fatal
Second generation antihistamines - less sedative but not useful in controlling prurits ad are you cardiotoic at high doses

Question 20

What do glucocorticoids do

Answer 20

Everything
Reduce swelling
Pain
Histamine
Vsolidation
Reduces everything

Question 21

Complication of glucocorticoids

Answer 21

Suppress wound healing
Gastric ulceration
Skin tinning if used topically

Question 22

Glucocorticoids use

Answer 22

Allergic disease -asthma
Life threatening swelling - laryngeal oedema
Shock
Autoimmune disease

Question 23

Complications of NSAIDS

Answer 23

Gastrointestinal bleeding
Poor wound healing

Question 24

Uses of NSAIDs

Answer 24

Control of pain
Decrease swelling
Reduce fever

Question 25

What are tricyclic antidepressants mode of action

Answer 25

Recieved at synaptic cleft brings serotonin back up the axon and stops the transporters from taking in serotonin transmitters

Question 26

What are benzodiazepines

Answer 26

Enhances GABA binding to GABA receptors - blocks impulses between nerve cells in the blend - reduce the likelihood of nuerons firing an action potential

Question 27

Pheromones mode of action

Answer 27

Animals will actively pump Vomeronasal organ - Wind sucking in horses etc Causes G proteins to bind to the vomronasal organ

Question 28

What is the anaesthesia triad

Answer 28

Analgesia Muscle relaxation Control

Question 29

How do you gain general anesthesia

Answer 29

By using all 3 t sections of the triad = may have to use one or more anasthesia drug

Question 30

What are barbituates mode of cation