Anti Inflammatory Drugs

Question 1

Aspirin, Ketoprofen, diclofenac, meclofenamate, Ibuprofen 5 indications

Answer 1

Pain, Fever, Arthritis, Dysmenorrhea (pain during period), patent ductus arteriosis (heart defect)

Question 2

Aspirin, Ketoprofen, Diclofenac, meclofenamate Ibuprofen 3 short term use side effect, 1 aspirin specific

Answer 2

GI tract disturbance, skin disorder, blood disorder

Aspirin : aspirin-induced asthma

Question 3

Aspirin, Ketoprofen, Diclofenac, meclofenamate, Ibuprofen long term use side effect

Answer 3

Nephrotoxicity (due to reduced blood flow)

Question 4

Aspirin, acetaminophen, diclofenac, meclofenamate is anti-inflammatory. T/F?

Answer 4

F. Acetaminophen is not anti-inflammatory.

Question 5

Aspirin, ketoprofen, diclofenac, meclofenamate, ibuprofen is NSAID with short half life (1-5H). T/F?

Answer 5

T

Question 6

Meloxicam, Naproxen, Piroxicam is non-selective cox inhibitor (NSAID). T/F?

Answer 6

T

Question 7

Aspirin, acetaminophen, diclofenac is selective cox-2 inhibitor, T/F?

Answer 7

F, non-selective.

Question 8

NSAID with least toxicity

Answer 8

Naproxen

Question 9

ADE of NSAID

Answer 9

A : well absorbed orally
D : highly bound to plasma protein, accumulate in sites of inflam with lower pH
E : kidneys (glomerular / tubular secretion)

Question 10

NSAID with least GI irritation

Answer 10

Celecoxib, diflunisal

Question 11

NSAID with high chance of upper GI disturbance

Answer 11

Aspirin, indomethacin

Question 12

Very potent NSAID, used after less toxic agents are proven ineffective

Answer 12

Indomethacin

Question 13

3 indications for selective COX-2 inhibitor

Answer 13

acute pain, osteoarthritis, rheumatoid arthritis

Question 14

3 advantages of selective cox-2 inhibitor vs non-selective

Answer 14

less kidney damage
less GI tract disturbance
no inhibition of platelet aggregation

Question 15

3 disadvantages of selective cox-2 inhibitor

Answer 15

cardiovascular and liver disorder, potentially increase stroke

Question 16

drug that has antipyretic and analgesic properties but not anti-inflammatory

Answer 16

acetaminophen

Question 17

Rofecoxib, celecoxib, valdecoxib have less kidney damage compared to aspirin. T/F?

Answer 17

T

Question 18

Celecoxib should be given to a patient with dysmenorrhea who has a heart condition. T/F?

Answer 18

F. avoid selective NSAIDS for patients with heart and liver condition

Question 19

Celecoxib should be given to a patient with osteoarthritis who has a compromised kidney function. T/F?

Answer 19

T

Question 20

Aspirin, ketoprofen, fenoprofen, ibuprofen can inhibit blood clotting. T/F?

Answer 20

T. They are non-selective COX inhibitors, and can inhibit blood clotting.

Question 21

Fluticasone, and prednisone are short-medium acting glucocorticoids. T/F?

Answer 21

T

Question 22

2 long acting glucocorticoid

Answer 22

dexamethasone, betamethasone

Question 23

Which SAID can be used as imunosupressant?

Answer 23

dexamethasone, betamethasone (long acting NAIDS)

Question 24

prednisolone causes constipation. T/F?

Answer 24

F.

Question 25

SAIDS can be used to treat conditions caused by allergies. T/F?

Answer 25

T

Question 26

Cortisone, prednisolone, dexamethasone, ibuprofen, ketoprofen, diflunisal, valdecoxib, rofecoxib. Group these into non selective, selevtice NSAIDS and also SAIDS

Answer 26

non-selective NSAID : profens + diflunisal selective NSAID : coxibs SAIDS: sone, solone

Question 27

Which anti-inflammatory group can be used to treat psoriasis and eczema? name 3 examples

Answer 27

SAIDS (glucocorticoids). Dexamethasone, prednisolone, hydrocortisone

Question 28

Which glucocorticoids are available for topical use?

Answer 28

betamethasone, dexamethasone (long acting) triamcinolone (medium acting) hydrocortisone (short-medium acting)

Question 29

which glucocorticosteroids are not injectable?

Answer 29

cortisone, prednisone, fluprednisolone, fludrocortisone

Question 30

Which glucocorticoids are available orally?

Answer 30

All are.

Question 31

Can glucocorticoid use be stopped abruptly? Why?

Answer 31

No, can cause acute adrenal insufficiency

Question 32

NSAIDS used as first line treatment of primary dysmenorrhea (no underlying condition that cause dysmenorrhea)

Answer 32

mefenamic acid ibuprofen Celecoxib naproxen source: american family physician 2014

Question 33

The first line treatment of acute gout attack (asam urat >6mg/dL) that does not require a prescription is?

Answer 33

diclofenac (sodium diklofenak), an NSAID

Question 34

3 non-selective NSAIDS that has higher affinity for cox-2 receptors

Answer 34

meloxicam diclofenac (sodium diklofenak) etodolac

Question 35

asam mefenamat merupakan obat wajib apotek. T/F?

Answer 35

T