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MSRA Surgery > Anti-oestrogen drugs > Flashcards

Anti-oestrogen drugs Flashcards

1
Q

What is an example of a selective oestrogen receptor modulator (SERM)?

A

Tamoxifen

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2
Q

How does tamoxifen/SERM?

A

oestrogen receptor antagonist/partial agonist

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3
Q

When is Tamoxifen used?

A

management of oestrogen receptor positive breast cancer

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4
Q

what are the adverse effects of tamoxifen?

A

menstrual disturbance: vaginal bleeding, amenorrhoea
hot flushes - 3% of patients stop taking tamoxifen due to climacteric side-effects
venous thromboembolism
endometrial cancer

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5
Q

What are examples of aromatase inhibitors?

A

Anastrozole and letrozole

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6
Q

How do aromatase inhibitors/ anastrozole and letrozole work?

A

reduces peripheral oestrogen synthesis

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