Anti-Parkinson's Drugs Flashcards
Levodopa/Carbidopa SEs.
N and v, orthostatic hypotension, dyskinesia hallucinations confusion, long term use causes mydriasis and precipitation of glaucoma and melanoma
COMT inhibitors SEs.
Dyskinesia nausea sleep disorders anorexia diarrhea hallucinations
Amantadine SEs
Anticholinergic SEs, hallucinations, edema of feet ankles
Levodopa to dopamine is catalyzed by what enzyme?
DOPA decarboxylase
Anticholinergic drugs SEs
Dry mouth, Blurred vision, Dry eyes, Constipation, Urinary retention
Avoid in elderly, aggravates glaucoma, memory impairment
Non Ergoline agonists, are selective to what receptors? Give examples
Selective D agonist drugs, full agonist on D2 and D3 receptors.
Pramipexole, Ropinirole, Ritigotine
Ergoline agonists, ergot alkaloids, are non selective to what receptors? Give examples
Non-selective D agonists, partial D1 and full on D2 and other receptors.
Bromocriptine and Cabergoline
MOA and examples, SE of COMT inhibitors.
COMT metabolizes L, inhibitors increases L availability to CNS
Tolcapone has hepatotoxicity and Entacapone none, diarrhea and discoloration of urine
MAO B Type inhibitors. Explain.
Selegiline < Rasagiline potency
SE insomia
Selegiline may need dec. dose for women w OCPs
Anticholinergic drugs for Parkinsons.
Benztropine, Trihexyphenidyl, Ethonopropazine, Procyclidine
Levodopa is catalyzed by what enzyme to 3-O-methyldopa?
COMT Cathecholamine O-Methyltransferase
Acronym meaning for LEVODOPA
L=DOC for parkinsons, E=empty stomach, V=n and v, O=orthostatic hypotension, D=dyskinesia/Domperidone for n and v, P=protein diet avoid, A=avoid VB6
Why is VB6 avoided with Levodopa?
VB6 (Pyridoxal phosphate) is a required cofactor of L-dopa to Dopamine= increases L metabolism , decreases efficacy
An antiviral drug used for L induced dyskinesia in later stages of disease.
Amantadine-NMDA receptor antagonist
