Steroid hormones

Question 1

SAR. This is essential for glucocorticoid activity.

This increases Gcort activity without increasing MC activity.

Answer 1

O2 at C-11

Double bond between C1 and C2

Question 2

Increases both MC and G activity

Increases G and less on MC activity.

Answer 2

Fluorination at C9

Fluorination at C6

Question 3

Formed in the outer layer of adrenal cortex, prototypical MC.
Middle layer.

Answer 3

Aldosterone

Cortisone

Question 4

Ring system of Steroids and the skeleton.

Answer 4

fused 17-carbon atom ring system

three 6 member cyclohexane rings and 1 cyclopentane

Question 5

Topical glucocorticoids potency ranking
Very high potency
High potency 
Medium potency
Low potency

Answer 5

VHP: Betamethasone (0.05%) dipropionate, Clobetasol (0.05%)
HP: Amcinonide, Triamcinolone
MP: Beta benzoate (0.025%) Triam 0.025-0.1%
LP: Dexamethasone and Hydrocortisone

Question 6

Inhaled and intranasal corticosteroids,
highly potent nonhalogenated steroid.
Quick onset, more local absorption and lowest systemic absorption, fewest systemic SEs

Answer 6

Budesonide

Mometasone

Question 7

SARs of steroidal hormones.

Answer 7

Estrogen phenolic group

Progesterone ethinyl group

Question 8

Increase in cortisone cause

Answer 8

Hypercorticoids - Cushing’s Disease

Question 9

Decrease in cortisone cause

Answer 9

Hypocorticoids - Addison’s Disease

Question 10

Glutathione is what type enzyme?

Testosterone?

Answer 10

Metabolic enzyme

Anabolic enzyme

Question 11

Major factor that controls Na excretion in kidneys.

Answer 11

Aldosterone

Question 12

Calcium reabsorption occurs where due ti pituitary hormone?

Answer 12

Distal convoluted tubule