Anti-parkinsonism

Question 1

This drug should not be given with MAO inhibitor as this may result to

Answer 1

Hypertensive crisis

Question 2

What drug should not be given with apomorphine that it may precipitate hypotension

Answer 2

5-HT3 antagonist

Question 3

Cardiac valvulopathy is observed in patient on this medication

Answer 3

Pergolide

Question 4

Drugs that induced parkinsonism

Answer 4

Reserpine - depletes monoamine storage

Haloperidol - blocks dopa receptor

Question 5

Acts both centrally and peripherally COMT inhibitor

Answer 5

Tolcapone

Question 6

Cardiovascular effect of L-Dopa

Answer 6

Tachycardia
Postural hypotension
Hypertension

Question 7

What trial evaluate the neuroprotective benefit of MAO-inhibitors

Answer 7

ADAGIO

Question 8

Most common side effect of L-dopa

Answer 8

Anorexia, nausea and vomiting

Question 9

Peripheral COMT-inhibitor

Answer 9

Entacapone

Question 10

This is more potent in MPTP induced parkinsonism

Answer 10

Rasagaline

Question 11

What exacerbates the GI adverse effect of L-dopa and should be avoided

Answer 11

Phenothiazine

Question 12

Ergot derivatives stimulates both D1 and D2

Answer 12

Pergolide

Question 13

Elimination of Pramipexole is thru

Answer 13

Renal

Question 14

Mechanism of action of Pramipexole

Answer 14

1. D3 agonist
2. scavenge hydrogen peroxide
3. enhance neutrophic activity in mesencephalic dopaminergic cell culture

Question 15

Adverse effect of Entacapone and Tolcapone

Answer 15

orange discolioration of urine
Dyskinesia
nausea
elevated live enzymes (tolcapone)

Question 16

Peak plasma concentration of Levodopa

Answer 16

1-2 hours

Question 17

Contraindication for L-DOpa

Answer 17

1. Known psychotic patients
2. Angle-Closure glaucoma
3. Bleeding gastric ulcer
4. Active malignant melanoma

Question 18

Levodopa effects usually diminishes after how many years

Answer 18

3-4 years

Question 19

Contraindication in using ergot derivatives

Answer 19

Peripheral vascular disease

Question 20

Reason for L-dopa non-responders

Answer 20

Loss of dopaminergic nigostriatal nerve terminals

Question 21

This drug may cause digital vasospasm

Answer 21

Bromocriptine

Question 22

What are the 3 drugs combination of Stalevo

Answer 22

Levodopa, carbodpa and entacapone

Question 23

This is a non-ergot derivatives that has preferential affinity rto D3 family receptors

Answer 23

Pramipexole

Question 24

half life of amantadine

Answer 24

2-4 hours

Question 25

What is the mechanism of behavioral effects of L-Dopa

Answer 25

Common in patient on carbidopa because higher level reach the brain

Question 26

D2 agonist

Answer 26

Bromocriptine

Question 27

Adverse effects of Amantadine

Answer 27

``` Livedoreticularis Peripheral eddema Restlessness Hallucination Caurtion in patient with hepatic and seizure ```

Question 28

Pergolide is not being used because of this

Answer 28

Development of valvular heart disease

Question 29

Mechanism of action of Apomorphione

Answer 29

Non-ergonaline Dopa agonist in postsynaptic D2 receptor in caudate and putamen

Question 30

Half-life of levodopa

Answer 30

1-3 hours

Question 31

What is the mechanism of Ropinirole

Answer 31

Pure D2 receptor agonist

Question 32

Mechanism of action of Amantadine

Answer 32

1. Potentiate dopaminergic function by influencing synthesis, release or reuptake of dopamine 2. Antagonize A-2A receptor that inhibit D2 receptor function

Question 33

Mechanism of action of Selegeline

Answer 33

irreversible MAO-B inhibitor

Question 34

What medication improves tremor and rigidity

Answer 34

Anti muscarinic | Benztropine, biperiden, trihexyphenidyl

Question 35

This medication reduces the amplitude of tremor

Answer 35

Propanolol

Question 36

May result with Serotonin syndrome if given with the following drugs

Answer 36

SSRI and TCA

Question 37

How is Ropinirole metabolize

Answer 37

CYP1A2

Question 38

This is a skin patch that is a dopamine agonist

Answer 38

Rotigotine

Question 39

Reason fro GI upset with L-Dopa

Answer 39

Stimulation of CTZ

Question 40

This drug depletes cerebral dopa and reduces the severity of chorea in HD

Answer 40

Tetrabenzine

Question 41

Mechanism of action of COMT inhibitors

Answer 41

Prolong action of L-dopa by diminishinh peripheral metabolism

Question 42

Erythromyelgia can be seen in this dopa agonist

Answer 42

Pramipexole and ropinirole

Question 43

Product of excretion of Dopamine are

Answer 43

HVA and Dihydroxyphenelyacetic acid

Question 44

What medication enhances the extracerebral metabolism of L-Dopa

Answer 44

Vitamin B6

Question 45

Duration of effect of apomorphine

Answer 45

10mins to 2 hours