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Neuropharma > Anti-psychotics > Flashcards

Anti-psychotics Flashcards

(48 cards)

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1
Q

Blocking of D2 receptor is strongly related to

A

EPS

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2
Q

Drug interaction of Lithium

A

Decrease clearance if given with thiazide and prostaglandin

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3
Q

Dopamine receptor that is found in the cortex only

A

Dopamine 4

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4
Q

Example of Aliphatic Phenothiazine

A

Chlorpromazine

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5
Q

Receptor affinity of Haloperidol

A

D2 > Alpha-1

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6
Q

What is the mechanism of action of lithium (2)

A
  1. suppresses inositol signal thru depletion of intracellular inositol
  2. Inhibit glycogen synthase kinase (GSK-3)
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7
Q

What antipsychotic that causes retinal deposition resembling retinitis pigmentosa

A

Thioridazine

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8
Q

What is the mechanism of developing neuroleptic malignant syndrome

A

Excess rapid blockade of postsynaptic dopamine receptor

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9
Q

Antipsychotic drug than can cause seizure

A

Chlorpromazine

Clozapine

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10
Q

Receptor affinity of Quetiapine

A

H1>Alpha1>M1>D2>5HT2A

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11
Q

Akathisia and Dystonia can be ameliorated by

A

Diphenhydramine

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12
Q

Aggranulocytosis occurs in this antipsychotic medication

A

Clozapine (6-8th week)

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13
Q

This antipsychotic causes DM and gain weight

A

Clozapine and olanzapine

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14
Q

If parkinsonism arise secondary from antipsychotic medication what can be given?

A

Antiparkinsonism of antimuscarinic type

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15
Q

What class of antipsychotics causes Prolongation of QT interval

A

Ziprasidone

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16
Q

What medication causes anterior deposits in the eye

A

Chlorpromazine

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17
Q

This medication has both D2 and 5HT2A antagonist and has greater effect as negative symptoms of schizophrenia

A

Caprizapine

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18
Q

Receptor affinity of Chlorpromazine

A

Alpha1=5HT2A>D2

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19
Q

Adverse effect of lithium

A 
Tremor
Subclinical hypothyroidism
Nephrogenic DI  - low response to ADH
Edema
Sick sinu syndrome
Acneiform eruption
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20
Q

Among the atypical antipsychotic, which is the least can cause weight gain

21
Q

Receptor affinity of Clozapine

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A

D4=Alpha1>5HT2A

22
Q

How does VPA works in Bipolar

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A

Indirectly inhibit GSK-3 causes upregulation thru inhibition of histone deacetylase
Inhibits inositol depletion mechanism

23
Q

Atypical antipsychotics alter what NT

24
Q

This antipsychotic may cause T-wave changes, torsades and cardiac conduction blocks

25
Dopamine receptor that decreases CAMP
Dopamine 3 4 and 5
26
Glutamate receptor
Group I - mGlur 1 and 5 Group 2 - mGlur 2 and 3 Group 3 - mGlur 4678
27
Reason for polyuria and subclinical hypothyroidism in lithoum
Uncoupling of receptor from G protein (vasopressin and TSH)
28
What is the mechanism of tardive dyskinesia induced by antipsychotics
Due to supersensitivity of dopamine receptor in the caudate and putamen
29
Chromosome involved in Bipolar Disorder
8p and 13q
30
Mechanism of action of Aripriprazole
1. Partial D2 receptor agonist | 2. Partial agonist of 5HT2A and 1A
31
Plasma concentration of lithium
0.6-1.4meg/L
32
This atypical antipsychotic produces elevation of prolactine
Risperidone
33
Volume of distribution of lithium
0.5L/kg
34
Dopamine receptor where typical antipsychotics medication takes place
D2
35
Receptor affinity of Olanzapine
5-HT2A>H1
36
Describe D1 receptor
Chromosome 5 | Increases CAMP
37
Affinity of Thioxanthene
very high D2 / 5-HT2A rational
38
maintenance level of lithium
0.6-0.9meq/L
39
Effect of lithium on second messenger
1. inhibit IMPase -> fail conversion of inositol | 2, Uncouple G protein
40
Treatment for neuroleptic malignant syndrome
Muscle relaxant BDZ Dantrolene Bromocriptine
41
This antipsychotic causes Myocarditis
Clozapine
42
This drug has equal potency for D2 and D3 but antagonist to 5HT 7
Sulpiride
43
Example of Thioxantene
Thiothioxene
44
These class of antipsychotic causes orthostatic hypotension, tachycardia
Phenothiazine
45
Example of Butyrophenone
Haloperidol
46
This antipsychotic reduces the risk of suicide
Clozapine
47
2 Types of Phenothiazine derivatives
1. Aliphatic | 2. Piperidine
48
Orthostatic hypotension and impaired ejaculation are the adverse effect of what antipsychotic
Chlorpromazine

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