Anti-platelet Flashcards
(12 cards)
What is the mechanism of action (MOA) of Aspirin?
Type of NSAID and a COX 1 and COX 2 inhibitor, blocks cyclooxygenase so prostaglandin and thromboxane are not synthesised which reduces the ability of platelets to aggregate.
What is the low-dose use of Aspirin?
Cardiovascular disease
What is the high-dose use of Aspirin?
Kawasaki disease (rare form of vasculitis)
What are examples of Glycoprotein IIb/IIIa receptor antagonists?
- Abciximab
- Tirofiban
- Eprifibatide
What is the primary use of Glycoprotein IIb/IIIa receptor antagonists?
PCI, ACS
What is the mechanism of action (MOA) of Glycoprotein IIb/IIIa receptor antagonists?
Inhibit the glycoprotein IIb/IIIa receptor, which inhibits fibrinogen bindings and cross-linking platelets - reducing thrombus formation.
What is a significant side effect of Glycoprotein IIb/IIIa receptor antagonists?
High risk of bleeding (including inter-cranial haemorrhage)
What are examples of Thienopyridines (ADP receptor/P2Y12 inhibitors)?
- Clopidogrel
- Prasugrel
- Ticagrelor
- Ticlopidine
What are the primary uses of Thienopyridines?
ACS, PCI, TIA, Stroke, peripheral arterial disease
What is the mechanism of action (MOA) of Thienopyridines?
Antagonists of the P2Y12 adenosine diphosphate (ADP) receptor, inhibiting the activation of platelets.
What should be avoided when prescribing PPI inhibitors with Clopidogrel?
Omeprazole/esomeprazole
What is the uses of anti-platelet therapy?
