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Flashcards in Anti-schizophrenic drugs Deck (19)
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1

Define schizophrenia in terms of +ve and -ve symptoms

A neurological conditions characterised by +ve symtoms (ones that shouldn't be there):
hallucinations(auiatory/visual)
delusions = paranoia
thought disorder = denial

and -ve symptoms (ones that should be present but aren't)
affective flattening
no pleasure from everyday activities
apathy/avolition = lack of motivation
alogia = lack of speech

2

DAergic pathways affected in schizophrenia and how?

Mesolimbic - increased DA -> +ve symptoms
Mesocortical - decreased DA -> -ve symptoms

3

Prevalance and cause of schizophrenia

1% population, strongly genetic

4

Name for antischizophrenic drugs

antipsychotics

5

Main MOA of antipsychhotics

Decreasing +ve symptoms

6

1st gen antipsychotics

Chlorpromazine
Haloperidol

7

MOA of Chlorpromazine and Haloperidol

D2R antagonists

8

SE of chlorpromazine

high incidence: anticholinergic, sedation
Low incidence: extrapyramidal symptoms

9

SE of haloperidol

high incidence EPS

10

2nd gen antipsychotics

Clozapine, risperidone, quetiapine, aripiprizole

11

MOA and use of chlozapine

5-HT2AR antagonist, most effective, used in resistant schizophrenias and reduces -ve symptoms

12

SE of chlozapine

potentially fatal neutropenia, agranulocytosis, myocarditis, weight gain

13

MOA of risperadone

5-HT2AR and D2R antagonist

14

SE of risperadone

more EPS and hyperprolactinaemia

15

Pharmacodynamic feature of all antipsychotics

multiple affinities to a range of receptors
typically dirty drugs, non-specific

16

MOA of quitiapine

H1R antagonist

17

SE of quitiapine

lower incidence of EPS

18

MOA of aripiprizole

partial agonist of D2R and 5-HT1AR (therefore acts as an antagonist when activity too high and agonist when activity too low)

19

SE of aripiprizole

lower incidence of weight gain and hyperprolactinaemia