Anti-TB

Question 1

Category I Indication (3)

Answer 1

New PTB
New Miliary TB
New ETB (except CNS/ bones/ joints)

Question 2

Category I Regimen

Answer 2

2HRZE
4HR

6 months total

Question 3

Category Ia Indication (2)

Answer 3

CNS TB

TB bones/joints

Question 4

Category Ia Regimen

Answer 4

2HRZE
10 HR

12 months total

Question 5

Category II Indication (1)

Answer 5

Retreatment of Rif susceptible PTB & ETB (except CNS/bones/joints)

Question 6

Category II Regimen

Answer 6

2HRZES
1HRZE
5HRE

8 months total; Mawawala muna si S tas si Z

Question 7

Category IIa Regimen

Answer 7

2HRZES
1HRZE
9HRE

12 months total

Question 8

Rifampicin (R) MOA

Answer 8

(-) RNA polymerase

Question 9

Isoniazid (H) MOA

Answer 9

(-) enoyl reductase

(-) mycolic acid layer synthesis

Question 10

Pyrazinamide (Z) MOA

Answer 10

Dec. pH -> disturb membrane transportation & permeability

(-) uptake of uracil, methionine, serine

Question 11

Ethambutol (E) MOA

Answer 11

Arabo si Ethan na di pumapatay

(-) Arabinosyl-transferase
(-) Arabinogalactan layer

Question 12

Streptomycin (S) MOA

Answer 12

(-) 30s

Question 13

When giving this anti-TB drug, always give vitamin B complex (part. Vit. B6) to prevent peripheral neuropathy

Answer 13

Isoniazid

Question 14

Isoniazid Mechanism of Resistance (MOR)

Answer 14

Mutation in KAtG gene

Question 15

Rifampicin MOR

Answer 15

Mutation in rpoB gene (most common mutation in ant-tb)

Question 16

Pyrazinamide MOR

Answer 16

Mutation in pncA gene

Question 17

What do you call the ability of Anti-TB drugs to kill all remaining organism?

Answer 17

Sterilizing activity

Question 18

Which of the anti-TB has sterilizing activity? (2)

Answer 18

steRiliZing

Rifampicin
Pyrazinamide

Question 19

Which of the anti-TB targets intracellular bacilli only?

Answer 19

Pyrazinamide

Question 20

Pyrazinamide ADR

Answer 20

Hyperuricemia

Question 21

Ethambutol ADRs (2)

Answer 21

Optic Neuropathy
RED-GREEN color blindness (Christmas colors)

BLUE-GREEN? = Sildenafil (Viagra)

Question 22

Reasons to use 2nd line Anti-TB drugs? (3)

Answer 22

1. 1st line are not available
2. Severe ADR
3. Resistance

Question 23

The last resort in the tx of TB MDR; Tx for Hansen’s Dse

Answer 23

Clofazimine

Question 24

Bedaquilline MOA

Answer 24

(-) mycobacterial ATP synthase/ complex 5 of ETC

Question 25

Delamanid MOA

Answer 25

(-) mycolic acid biosynthesis

Question 26

Acid Fast (CAM)

Answer 26

C -Carbol Fuhsin A- Acid Alcohol VS (Acetone Alcohol in GS) M- Malachite green

Question 27

Complex Lipid present in peptidoglycan of TB is composed of (4)

Answer 27

Arabinoglycan layer Mycolic Acid Cord Factor Wax D

Question 28

Mendel-Mantoux test is what type of hypersensitivy?

Answer 28

Type IV Delayed Type | Only type that that is T-cell mediated

Question 29

TST > 10mm is normal | Who are >5mm, positive na?

Answer 29

``` 4C immunoCompromised Close Contact Clinical S/Sx Chest Xray ```

Question 30

Px with both PTB and ETB, what is the classification?

Answer 30

PTB pa rin mga olol

Question 31

Px has hx of TB and now is taking TB drugsfor 3 weeks. Classification?

Answer 31

New case. Cut off: 1 month > 1 month = Retreatment

Question 32

Why do we have 4 drugs in the initiation phase of TB tx?

Answer 32

To dec. resistance

Question 33

Retreatment involves ?

Answer 33

Streptomycin

Question 34

Streptomycin is administered?

Answer 34

Intramuscularly (IM)

Question 35

Pyrazinamide is a prodrug it is activated inside the cell and becomes?

Answer 35

Pyrazinoic acid

Question 36

All anti-TB drugs are bacteriocidal except

Answer 36

Ethambutol

Question 37

Which of the anti-TB targets extracellular bacilli only?

Answer 37

Streptomycin

Question 38

All anti-TB drugs are hepatotoxic but the most hepatotoxic are? (2)

Answer 38

Pyrazinamide | Isoniazid

Question 39

What anti-TB drug can cause drug-induced lupus?

Answer 39

Isoniazid

Question 40

The most common ADR of Isoniazid is?

Answer 40

Peripheral Neuropathy Vit B6

Question 41

What anti-TB drug can cause red-orange secretions?

Answer 41

Rifampicin Luha, ihi orange

Question 42

Which of the ff. novel anti-TB drugs has the same MOA w/ Isoniazid?

Answer 42

Delamanid