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GI Drugs Flashcards

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1
Q

Cell responsible for the secretion of H+ and Intrinsic factors in the stomach?

A

Parietal/ Oxyntic cells

Oxyphil - parathyroid

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2
Q

Mucus neck cells?

A

HCO3

micarmomate

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3
Q

G cells?

A

Gastrin

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4
Q

Chief/ Zymogenic cells?

A

Pepsinogen

chief ng pep squad

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5
Q

Entero-Chromaffin Like cell?

A

Histamine

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6
Q

Stimuli of H+/K+ ATPase (3)

A

ACH - M3
H2 - H2 Receptor
Gastrin

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7
Q

Antacids capable of being absorbed in the stomach?

A

Sodium bicarb

Calcium bicarb

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8
Q

pHGoals

A 
3= healing ulcer
4= stress ulcer
6= bleeding ulcer
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9
Q

H2 antagonist - ring

A

cIMEtidine - imidazole
RANitidine - fuRan
NniZAtidine, fAmotidine - Thiazole

cross placenta, not teratogenic, rapid hepatic metab

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10
Q

H2 antagonist w/ endocrine side effects?

A

Cimetidine

Same as ketoconazole

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11
Q

Aripripazole is nor a PPI, but a ?

A

Antipsychotic

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12
Q

MOA of PPI?

A

Irreversibly block the PP- 18-24 hours for parietal cell to make PP

SHORT half life

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13
Q

All PPIs are prodrug. Converted in the intestines but destroyed by gastric acid. So dosage form is?

A

ENTERIC COATED

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14
Q

PPIs arrangement based on bioavailability?

A 
L-PERO
Lantoprazole
Pantoprazole
Esomeprazole
Rabeprazole
Omeprazole
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15
Q

All PPIs are renally excreted except?

A

Lantoprazole - Biliary

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16
Q

GI Bleeding sign.

A

80mg/IV bolus then constant infusion 8mg/hour

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17
Q

Omeprazole interacts w/ ?

A

Clopidogrel

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18
Q

PPI affect absorption of ? ? ? ?

A

B12
Fe
Ca
Zinc

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19
Q

PGE analogue that inc. mucus/HCO3

20
Q

All prostaglandins are vasoconstrictors except ? and ?

Study These Flashcards
A

PGE
PGI

All mcdonalds had a farm E I EI O vasodilator

21
Q

Which of the ff. mucosal protective have anti-microbial effects?

Study These Flashcards
A

Bismuth salts

22
Q

ADR of Bismuth Salt?

Study These Flashcards
A

Blackening of the stool and gums

23
Q

Factors that increase gastric motility? (3)

Study These Flashcards
A

GAM
Gastrin
ACH
Motilin

24
Q

Which of the ff. increase BOTH acid sec. and gastric motility? (2)

25
Dopamine _____ motility
INHIBITS D gagalaw
26
Dopamine is also known as?
Prolactin inhibitory hormone
27
Metoclopramide is a D2 antagonist and has this endocrine side effect?
Hyperprolactinemia = Galactorrhea Tx: Dopamine agonist like BROMOCRIPTINE
28
D2 antagonist that doesn't cross the BBB and is for post partum lactation?
Domperidone
29
MOA of Erythromycin for being prokinetic agent?
promotes MOTILIN RELEASE
30
CIs of laxatives?
ACUTE abdominal disorders Appendicitis Diverticulitis Ulcerative Colitis why? risk of bowel rupture sis
31
Bulk Forming Laxatives
Methylcellulose Psyllium Polycarbophil
32
MOA of Bulk Forming
absorbs water soften and enlarge stool fecal swelling -> peristalsis
33
Only laxative that can be used chronically?
BULK forming
34
Osmotic laxatives
Magnesium hydroxid (Millk of Magnesia) Lactulose, sorbitol Glycerin (suppository)
35
Surfactant laxatives/ Emollient/ Stool softners MOA?
Lowers surface tension -> facilitates water penetration Ex. DOCUSATE SALTS
36
Stimulant Laxatives ex.
Phenopthalein Bisacodyl MOA: Stimulates peristalsis
37
Lubricant Laxatives MOA?
Interferes with H20 and fat absorption Ex. MINERAL OIL
38
MOA of Simethicone?
Breaks gas bubbles = antiflatulence
39
Agent for whole bowel irrigation? (bowel evacuant)
Polyethylene glycol
40
MOA of 5-ASA/ Mesalamine for IBD
Inhibits synthesis of PGs and inflam. leukotrienes
41
5-ASA/ Mesalanin is a __ therapy for IBs
topical - pinapahid sa mucosal surface
42
A 5-ASA that can cause SJS?
Sulfasalazine
43
5-ASA for Jejunum-Rectum
Pentasa
44
5-ASA for the colon only? (2)
Sulfasalazine Balsalazide Ulcerative colitis
45
5-ASA for Ileum-Rectum
Asacol | Lialda
46
5-ASA for Sigmoid-rectum?
Rowasa
47
5-ASA for Rectum?
Canasa

Pharmacology (13 decks)

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