Antiarrhythmics Flashcards Preview

Pharm quiz 8 > Antiarrhythmics > Flashcards

Flashcards in Antiarrhythmics Deck (18)
Loading flashcards...
1

Class 1A

Increase action potential duration

- Quinidine
- Procainamide
- Disopyramide

2

Class 1B

Shorten duration of action potential and refractory period

- Lidocaine
- Mexiletine

3

Class 1C

Little or no effect on duration of action potential or refractory period

- Flecainide
- Propafenone

4

Class II

Beta Blockers

Propanolol
Metropolol
Timolol

5

Class III

K channel blockers

Sotalol - torsades / CHF
Ibutilide - torsades, Long Q-T
Dofetilide - Bradycardia, Hypokalemia
Amiodarone - CYP 3A4, CYP 450, adrs below

6

Class IV

Ca channel blockers

Supraventricular Arrhythmias
Verapamil
Diltiazem

7

Class I, general

Na channel blockers, local anesthetic action

8

Quinidine (Class 1A) ADRs

Atrail flutter / fibrillation
Ventricular Arrhythmias

Torsades
Syncope
Hypotension
GI

9

Procainamide (Class 1A) ADRs

Best for Ventricular Arrhythmias

Torsades
Syncope
Hypotension
GI

10

Disopyramide (Class 1A) ADRs

CYP450

Ventricular Arryhthmias

Torsades de Pointes
CHF symptoms
QT prolongation

11

Lidocaine (Class 1B)

** 1st line Ventricular Arrhythmias from MI **

Hypotension
Neuro: lightheadedness, tremor, hearing disturbances

12

Mexeletine (Class 1B) ADRs

Not used any more? Chronic Ventricular Arrhythmias?

13

Flecainide (Class 1C) ADRs

A Fib

May cause severe exacerbation of arrhythmias w pre existing ventricular tachy / previous MI

14

Propafenone (Class 1C) ADRs

Atrail Fib, Atrial Flutter

Beta Blocker Effect

Hypotension
Constipation
Metallic taste

15

Drug of choice for prompt conversion of paroxysmal supraventricular tachycardia to sinus rhythm

Adenosine

ADRs -
SOB
Hypotension
Headache
Nausea

16

Used in:
Digitalis induced arrhythmias
Torsade de pointes
Sinus tachycardia

Magnesium

17

decreases conduction of electrical impulses through the AV node and increases vagal activity via its central action on the CNS

Digoxin

18

Amiodarone ADRs

Blue skin,
bradycardia,
abnormal liver function tests
corneal opacity / blindness,
pulm toxicity,