Flashcards in Antiarrhythmics Deck (18)
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1
Class 1A
Increase action potential duration
- Quinidine
- Procainamide
- Disopyramide
2
Class 1B
Shorten duration of action potential and refractory period
- Lidocaine
- Mexiletine
3
Class 1C
Little or no effect on duration of action potential or refractory period
- Flecainide
- Propafenone
4
Class II
Beta Blockers
Propanolol
Metropolol
Timolol
5
Class III
K channel blockers
Sotalol - torsades / CHF
Ibutilide - torsades, Long Q-T
Dofetilide - Bradycardia, Hypokalemia
Amiodarone - CYP 3A4, CYP 450, adrs below
6
Class IV
Ca channel blockers
Supraventricular Arrhythmias
Verapamil
Diltiazem
7
Class I, general
Na channel blockers, local anesthetic action
8
Quinidine (Class 1A) ADRs
Atrail flutter / fibrillation
Ventricular Arrhythmias
Torsades
Syncope
Hypotension
GI
9
Procainamide (Class 1A) ADRs
Best for Ventricular Arrhythmias
Torsades
Syncope
Hypotension
GI
10
Disopyramide (Class 1A) ADRs
CYP450
Ventricular Arryhthmias
Torsades de Pointes
CHF symptoms
QT prolongation
11
Lidocaine (Class 1B)
** 1st line Ventricular Arrhythmias from MI **
Hypotension
Neuro: lightheadedness, tremor, hearing disturbances
12
Mexeletine (Class 1B) ADRs
Not used any more? Chronic Ventricular Arrhythmias?
13
Flecainide (Class 1C) ADRs
A Fib
May cause severe exacerbation of arrhythmias w pre existing ventricular tachy / previous MI
14
Propafenone (Class 1C) ADRs
Atrail Fib, Atrial Flutter
Beta Blocker Effect
Hypotension
Constipation
Metallic taste
15
Drug of choice for prompt conversion of paroxysmal supraventricular tachycardia to sinus rhythm
Adenosine
ADRs -
SOB
Hypotension
Headache
Nausea
16
Used in:
Digitalis induced arrhythmias
Torsade de pointes
Sinus tachycardia
Magnesium
17
decreases conduction of electrical impulses through the AV node and increases vagal activity via its central action on the CNS
Digoxin
18
