Antiarrhythmics Flashcards
(18 cards)
Class 1A
Increase action potential duration
- Quinidine
- Procainamide
- Disopyramide
Class 1B
Shorten duration of action potential and refractory period
- Lidocaine
- Mexiletine
Class 1C
Little or no effect on duration of action potential or refractory period
- Flecainide
- Propafenone
Class II
Beta Blockers
Propanolol
Metropolol
Timolol
Class III
K channel blockers
Sotalol - torsades / CHF
Ibutilide - torsades, Long Q-T
Dofetilide - Bradycardia, Hypokalemia
Amiodarone - CYP 3A4, CYP 450, adrs below
Class IV
Ca channel blockers
Supraventricular Arrhythmias
Verapamil
Diltiazem
Class I, general
Na channel blockers, local anesthetic action
Quinidine (Class 1A) ADRs
Atrail flutter / fibrillation
Ventricular Arrhythmias
Torsades
Syncope
Hypotension
GI
Procainamide (Class 1A) ADRs
Best for Ventricular Arrhythmias
Torsades
Syncope
Hypotension
GI
Disopyramide (Class 1A) ADRs
CYP450
Ventricular Arryhthmias
Torsades de Pointes
CHF symptoms
QT prolongation
Lidocaine (Class 1B)
** 1st line Ventricular Arrhythmias from MI **
Hypotension
Neuro: lightheadedness, tremor, hearing disturbances
Mexeletine (Class 1B) ADRs
Not used any more? Chronic Ventricular Arrhythmias?
Flecainide (Class 1C) ADRs
A Fib
May cause severe exacerbation of arrhythmias w pre existing ventricular tachy / previous MI
Propafenone (Class 1C) ADRs
Atrail Fib, Atrial Flutter
Beta Blocker Effect
Hypotension
Constipation
Metallic taste
Drug of choice for prompt conversion of paroxysmal supraventricular tachycardia to sinus rhythm
Adenosine
ADRs - SOB Hypotension Headache Nausea
Used in:
Digitalis induced arrhythmias
Torsade de pointes
Sinus tachycardia
Magnesium
decreases conduction of electrical impulses through the AV node and increases vagal activity via its central action on the CNS
Digoxin
Amiodarone ADRs
Blue skin, bradycardia, abnormal liver function tests corneal opacity / blindness, pulm toxicity,
