antiarrhythmics

Question 1

what do class 1 drugs do

Answer 1

inhibit fast sodium channels

Question 2

IA drug examples

Answer 2

quinidine, procainamide, disopyramide, moricizine

Question 3

IB drug examples

Answer 3

lidocaine, mexilitine

Question 4

IC drug examples

Answer 4

flecainide, propafenone

Question 5

what do class II drugs do

Answer 5

decrease rate of depolarization

Question 6

example of class II drugs

Answer 6

Beta blockers

Question 7

what do class III drugs do?

Answer 7

inhibit potassium ion channels

Question 8

examples of class III drugs

Answer 8

amiodarone and sotalol

Question 9

what do class IV drugs do

Answer 9

inhibit slow calcium chanels

Question 10

Class IV drug examples

Answer 10

diltiazem and verapamil

Question 11

which drug has the active metabolite NAPA

Answer 11

procainamide. increases risk of s/e, QT prolongatoin

Question 12

T/F: All the 1A’s (procainamide, quinidine, disopyramide) are used for ventricular arrhythmias only.

Answer 12

FALSE. both atrial and ventricular

Question 13

which drug is a potent CYP2D6 inhibitor as well as a PGP inhibitors leading to multiple drug interactions?

Answer 13

Quinidine

Question 14

which drug is used in combination with dextromethophan to form Nuedexta?

Answer 14

quinidine

Question 15

T/F All the 1A’s (procainamide, quinidine, disopyramide) have the side effect of QT prolongation

Answer 15

TRUE

Question 16

which drug do you see SLE like syndrome with chronic administration?

Answer 16

Procainamide

Question 17

T/F Lidocaine is effective against supra ventricular arrhythmias

Answer 17

False. it is ineffective, and can make them worse

Question 18

T/F Lidocaine, as a 1B, blocks sodium channels.

Answer 18

TRUE

Question 19

what is Lidocaine’s effect on QT interval?

Answer 19

it has very little effect

Question 20

Which drug is indicated for ventricular arrhythmias, particularly re-entry dysrhythmias

Answer 20

Lidocaine

Question 21

which drug used to be used for Digoxin toxicity?

Answer 21

phenytoin. it suppresses ventricular dysrhythmias associated with dig tox

Question 22

T/F Phenytoin, as a 1B, blocks potassium channels.

Answer 22

FALSE. 1B’s block sodium channels

Question 23

Rapid administration of phenytoin can result in….?

Answer 23

resp arrest, severe hOtn, ventricular ectopy, death

CNS:drowsniess, nystagmus, nausea, vertigo

Question 24

T/F Flecanidie, as a 1C, blocks Na, K, and Ca channels.

Answer 24

TRUE

Question 25

T/F Flecainide has little pro-arryhtmic properties

Answer 25

FALSE - very significant arrhythmias

Question 26

which drug should you avoid in someone who has CAD, LV failure, VT due to its negative iontropic effects?

Answer 26

Flecainide

Question 27

which drug prolongs QRS?

Answer 27

flecainide

Question 28

which drug suppresses the SA node, similar to a CCB or BB?

Answer 28

Flecainide

Question 29

T/F: Recent studies have shown that in A-fib treatment, slowing the rate with BB vs controlling the rhythm with Amio has shown no difference in morbidity and mortality.

Answer 29

TRUE. | more side effects with amio.