Antibacterial and Antifungals Flashcards
Organisms not covered by cephalosporins
Listeria monocytogenes
Atypicals (chlamydia, mycoplasma)
MRSA
Enterococci
*LAME
Why you should avoid ceftriaxone in neonates?
They have decrease biliary metabolism
Risk when use imipenem or meropenem in a patient with renal dysfunction or if give overdose
Seizures
Antibiotic inhibitor of cell wall synthesis that doesn’t have cross allergenicity with penicillins or cephalosporins
Aztreonam
Which antibiotics bind to the 30S subunit of bacterial ribosomes?
Aminoglycosides
Tetracyclines
Antibiotic used for TBC, drug of choice for bubonic plague and tularemia
Streptomycin
Antibiotics of choice in pregnancy
Penicillins
Cephalosporins
Macrolides
Most likely cause of pseudomembranous colitis
Clindamycin
Why do the anaerobes are resistant to the aminoglycosides?
Aminoglycosides ▶️ Require O2 for uptake ▶️ ineffective against anaerobes
Toxoplasmosis treatment and prophylaxis
Treatment ▶️ sulfadiazine + pyrimethamine
Prophylaxis ▶️ TMP-SMX
Which antibiotics should not be taken with milk (Ca2+), antacids (Ca2+ or Mg2+), or iron-containing preparations?
Tetracyclines
Quinolones
Why quinolones must be avoided in children? Other articular side effect is?
Inhibition of chondrogenesis ▶️ In 60 yrs or prednisone
Treatment of Multidrug-resistant P aeruginosa, multidrug-resistant Acinetobacter baumannii
Polymyxins B and E (colistin)
Which azole antifungi can penetrate into CSF and used for meningeal infection?
Fluconazole
Mechanism of action of terbinafine. Indications.
Inhibit squalene epoxidase ▶️ ⬇️ ergosterol
Dermatophytes (onychomycoses)
