Antibiotic therapy Flashcards Preview

Pharmacology > Antibiotic therapy > Flashcards

Flashcards in Antibiotic therapy Deck (27):
1

Name the beta lactams

Penicillins, cephalosporins, monobactams, carbapenems

2

Beta lactams method of action

Inhibition of cell wall synthesis, by binding to penicillin binding proteins (PBP) and inactivating transpeptidase enzymes involved in cross linking peptidoglycans.

3

Augmentin

Amoxicillin + clavulonic acid

4

Zosyn (Tazocin)

Piperacillin + tazobactam (antipseudomonal penicillin)

5

Aminopenicillins

Amoxicillin, ampicillin

6

Macrolides

Erythromycin, Clarithromycin, azithromycin

7

Tetracyclines

Tetracycline, doxycycline, minocycline

8

Responsible for red man syndrome

Vancomycin

9

C.difficile treatment

First episode = metronidazole (10-14 days), second/severe episode = oral vancomycin

10

Bacterial meningitis treatment

Meningococcal - Penicillinw G or cefotaxime/ceftriaxone (if immediate hypersensitivity to penicillin/cephalosporins then chloramphenicol).
Pneumococcal, H.influenzae or unknown etiology - cefotaxime or ceftriaxone (if allergy then chloramphenicol)
Listeria - amoxicillin

11

Empirical therapy for pneumonia

Or Clarithromycin or doxycyclineAmoxicillin

12

Empirical therapy for UTI

Trimethoprim (oral), nitrofurantoin or amoxicillin

13

Quinolones

Ciprofloxacin, levofloxacin

14

Treatment for MRSA

MRSA pneumonia - glycopeptide (vancomycin)
MRSA bronchiectasis - tetracycline or clindamycin
MRSA skin/soft tissue infection - tetracycline +/- rifampicin and fucidic acid.
MRSA UTI - tetracycline
MRSA septicaemia - glycopeptide

Summary: tetracycline or a glycopeptide (vancomycin)

15

Purulent conjunctivitis

Chloramphenicol eye drops

16

Gastroenteritis

Self limiting, antibiotics not necessary

17

Salmonella

Only treat invasive/severe infection - ciprofloxacin or cefotaxime

18

Bacterial vaginosis

Oral or topical metronidazole (5 days) or topical clindamycin

19

Uncomplicated gonorrhea

Azithromycin single dose + contact tracing recommended

20

Osteomyelitis

Flucloxicillin (of MRSA suspected then vancomycin)

21

Septic arthritis

Flucloxacillin (if MRSA suspected then vancomycin)

22

Community acquired pneumonia (low severity)

Amoxicillin (7 days), alternatives - doxycycline, clarithromycin

23

Strep threat treatment

Phenoxymethylpenicillin

24

Acute COPD exacerbation

Amoxicillin or doxycycline or Clarithromycin

25

Otitis media in children

Amoxicillin (erythromycin if penicillin allergy)

26

Cellulitis treatment

Flucloxacillin (Clarithromycin if penicillin allergy)

27

Vancomycin

Glycopeptide active against Grame +ve- bloodstream MRSA infections. Directly inhibits cell wall synthesis.