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Flashcards in Pharm Questions Deck (19):
1

Classes of antidepressants


Tricyclic antidepressants
Monoamine Oxidase Inhibitors
Serotonin and noradrenaline Reuptake inhibitors (SNRIs)
Selective Serotonin Reuptake inhibitors (SSRIs)

2

Side effects of aminoglycosides

Ototoxicity
Nephrotoxicity

3

Ototoxicity drugs

Aminoglycosides
Loop diuretic (e.g. Furosemide)
Chemotherapeutics (e.g. Cisplatin, Carboplatin)

4

Cephalosporin side effects

Hypersensitivity
5% cross-allergenicity with penicillins

5

Monobactam (aztreonam) coverage

Only gram negative aerobes: pseudomonas, H.influenzae, N.meningitidis

6

Penicillin side effects

Hypersensitivity (from urticaria to anaphylactic shock)

Other
Maculopapular rash - amoxicillin
Diarrhoea/pseudomembraneous colitis - ampicillin

7

CYP inducers

P-CRABS: phenytoin, carbamezapine, rifampicin, alcohol (chronic use), barbiturates, St.John's Wort

8

CYP inhibitors

G-PACMAN: grapefruit, protease inhibitors, Azole antifungals, Cimetidine, Macrolides (except azythromycine), Amiodarone, Non-DHP CCBs

9

Acyclovir indications

HSV, VZV, CMV

10

Uses of benzodiazepines

First line management of seizures, status epilepticus, alcohol withdrawal.

Common choice for sedation during surgery.

Short term treatment of severe anxiety or severe insomnia.

11

Side affects of antiepileptics

Antiepileptic hypersensitivity syndrome, rare but potentially fatal.
Teratogenicity in pregnant women.
Interactions between antiepileptics
Withdrawal - must be done under specialist supervision.

12

Mechanism of action of antipsychotics

Dopamine antagonism

13

Side effects of dopamine blockade

Nigrostriatal - parkinsonian symptoms
Tubuloinfundibular - increased prolactin (dopamine in the inhibitor of prolactin release) = galactorrhea, amenorrhea etc

14

SSRI side effects

Sexual problems - reduced libido, difficulty reaching orgasm
Insomnia, anxiety, nausea

15

What is neuroleptic malignant syndrome

Rare, but life threatening idiosyncratic reaction to neuroleptics (antipsychotics)

16

Sedatives

Benzodiazepines and barbiturates

17

Mechanism of action of antipsychotics

Dopamine blockade

18

Dopamine hypothesis of psychosis

Excess dopamine is responsible for psychosis e.g. Positive symptoms of schizophrenia, side effects of levodopa treatment in Parkinsons

19

Side effects of typical antipsychotics

Extrapyramidal motor symptoms - Parkinson like, tardive dyskinesia.
Increase prolactin