Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

USMLE > Antibiotics > Flashcards

Antibiotics Flashcards

(58 cards)

Start Studying
1
Q

block 30s

A

tetracyclines, aminoglycosides (TAG)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

block 50s

A

chloramphenicol, clinda, linezolid, erythromycin (macrolides in general) (CLEan) + streptogramins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

DNA damage

A

metronidazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

block mRNA synthesis

A

rifampin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

block dna topoisomerase II

A

fluoroquinolones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

block folic acid synthesis

A

sulfonamides, trimethoprim

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

block peptidoglycan crosslinking

A

penicillins, cephalosporins, aztreonam, imipenem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

block peptidoglycan synthesis

A

bacitracin, vancomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

bacterostatic

A

clinda, chloramphenicol, linezolid, tetracyclines, spectinomycin, sulfonamides

CCliTSS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

toxicity of penicillin resistant penicillins

A

interstitial nephritis –> oxa/naf/diclox

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

aminopenicillins

A

ampi, amoxi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

mrsa resistance

A

altered pbp target - dala dala to dala dlac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

antipseudomonal penicillin

A

ticarcillin, piperacillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

beta lactamase inhibitors

A

clavulanate, sulbactam, tazobactam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

vitamin k defic

A

cephalosporins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

increase nephrotoxicity of aminoglycosides

A

cephalosporins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

imipenem must be given with ____

A

cilastatin which inhibits renal dehydropeptidase I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

vanc moa

A

binds d-ala-d-ala portion of cell wall precursors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

blocks 50s peptidyl transferase

A

chloramphenicol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

blocks 50s translocation

A

clinda, erythromycin (macrolides macroslides)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

blocks 30s A site

A

tetracycline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

blocks 30s initiation complex

A

aminoglycosides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

blocks 50s initator

A

linezolid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

requires O2 for uptake

Study These Flashcards
A

aminoglycosides –> cant be used for anaerobes

25
gray baby syndrome
chloramphenicol
26
tx of lepromatous leprosy
+ clofazimine
27
tx of tuberculoid leprosy
dapsone and rifampine
28
4 R's of rifampin
rna polymerase inhibitor revs up p450 red fluids rapid resistance if alone
29
blocks aribynosyltransferase
ethambutol - reduces carb polymerization of mycobacterium cell wall
30
optic neuropathy - red green color blindness
ethambutol
31
binds ergosterol and causes leak
ampho b "amphotericin tears holes" | nystatin
32
inhibit sterol synthesis
inhibit p450 that converts lanosterol to ergosterol azoles itra for opportunistic
33
toxicity of azoles
testosterone synthesis inhibition, liver fxn
34
blocks 5fu to cytosine deaminase
flucytosine - crypto meningitis with ampho b
35
inhibits beta glucan in cell wall synthesis
caspofungin - invaive aspergillosis, candida
36
inhibits squalene epoxidase
terbinafene - dermatophytes
37
inhibits microtubule function
griseosulvin - increase p450 and warfarin metabolism
38
inhibits heme polymerase
chloroquine
39
inhibit neuraminidase
zanamivir, oseltamivir
40
inhibits guanine nucleotide synthesis by competitive inhibition of imp dehydrogenase
ribavirin
41
blocks thymidine kinase
acyclovir - guanasine analog | ganciclovir
42
binds to pyrophosphate binding site of dna polymerase
foscarnet - pyroFOSphate analog - does not need viral activation
43
coadminister ____with cidofovir
probenicid to reduce nephrotoxicity | cidofovir blocks viral dnap
44
tx of aids
2x NRTIs + 1 NNRTI or 1 PI or 1 II
45
protease inhibitors end in
navir
46
3 NNRTIs
nevirapine, efavirenz, delavirdine: NED is not a nucleoside
47
integrase inhibitor
raltegravir
48
risk of zidinavir
nephropathy
49
risk of zdv/azt
anemia - used in pregancy for fetal transmision
50
pregancy adverse effect: kernicterus
sulfa
51
pregancy adverse effect: ototoxic
aminoglycosides
52
pregancy adverse effect: cartilage damage
fluoroquinolone
53
pregancy adverse effect: embryotoxic
clarithromycin
54
pregancy adverse effect: discolored teeth
tetracyclines
55
pregancy adverse effect: teratogenic
ribavirin, griseo
56
pregancy adverse effect: gray baby
chloramphenicol
57
which NRTI does not need activtion
tenofovir
58
which protease inhibitor can boost drug concentrations by inhibiting p450
ritonavir

USMLE (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions