Antibiotics Flashcards Preview

Pharmacology > Antibiotics > Flashcards

Flashcards in Antibiotics Deck (55)
Loading flashcards...
1

Aminoglycoside MOA

inhibit protein synthesis by binding to 30S ribosomal subunit

2

Aminoglycoside side effects

~BBW~ Nephrotoxicity (reversible) Ototoxicity (irreversible) Neuromuscular Blockade (reversible) Neurotoxicity

 

3

Aminoglycoside monitoring

Peaks & troughs

Monitor renal function throughout

4

Fluroquinolone MOA

Inhibit DNA replication

5

Fluroquinolone side effects

~BBW~ tendon rupture (>60 yo, steroids, transplant)

 

6

Fluroquinolone contraindications

Pregnancy

Lactation

CYP450 inhibitor = lots of drug interactions

7

Sulfonamide MOA

inhibit folic acid synthesis

8

Sulfonamide side effects

Steven-Johnson Syndrome

Sulfa rash

9

Nitrofuran MOA

Prevent cell wall synthesis

10

Metronidazole MOA

DNA stand breakage

11

Metronidazole side effects

~BBW~ possible carcinogen

12

Fluroquinolone indications

Pseudomonas

Moxifloxacin

13

Sulfonamide indications

MRSA

UTIs

can penetrate CNS

14

Metronidazole and indications

Flagyl

C. diff - first line

Bacterial vaginosis

Trichomoiasis (anaerobic)

Helicobacter pylori

15

PCN (all) MOA

Inhibit peptidoglycan linkage for cell wall synthesis

16

PCN-G indications

Sepsis

Endocarditis

Meningitis

17

PCN-G contraindications

Do not give with BCG

18

Antistaphylococcal PCNs

Dicloxiacillin

Oxacillin

Nafcillin

19

PCN-Gs

Betrizathine

Procaine

20

Antistaphylococcal PCN MOA

Synthetic beta-lactamase inhibition

Use for beta-lactamases

21

Antistaphylococcal PCN indications

Staph

Strep

Pneumococci

22

2nd generation PCNs

Ampicillin

Amoxacillin

23

2nd generation PCN indications

Sepsis

Endocarditis

Meningitis

Better absorbed than PCN-G

24

3rd generation PCNS

Carbenicillin

Ticaracilllin

25

3rd generation PCN indications

Hospitalized pneumonias

26

4th generation PCNs

Piperacillin

27

1st generation Cephalosporins

Cefadroxil

Cephalexin (Keflex)

Cefazolin (Ancef)

28

1st generation Cephalosporin indications

Good G+ activity, anaerobic coccii

Cellulitis - complicated (cefazolin) or uncomplicated (cephalexin)

Strep

Staph but not MRSA

Peptococcus

Peptostreptococcus

29

1st generation Cephalosporin side effects

GI

Allergic reaction

May cause C. diff colitis

30

2nd generation Cephalosporins and indications

Cefoxitin - GI surgery prophylaxis, peritonitis, diverticulitis

Cefuroxine - sinusitis, otitis, RTI, community pneumonia