Antibiotics Flashcards
(8 cards)
1
Q
Beta lactams
A
Target cell walls
Penicillin- ampicillin, amoxicillin- 5 classes
Cephalosporins- 4 generations
2
Q
5 classes of penicillins
A
Natural
Beta lactamase resistant
Aminopenicillins- increase activity against gram -ve (ampi/amox)
Extended agents
Augmented agents- resistant to effects of beta lactamases
3
Q
4 generations of cephalosporins
A
1st gen- gram -ve aerobes
2nd gen- gram -ve and +ve anaerobes
3rd gen- gram +ve and -ve aerobes
4th gen- extended activity, stable against beta lactamases
4
Q
Aminoglycosides
5things
A
Inhibit protein synthesis Bactericidal Synergistic with beta lactams (pen strep) Eliminated unchanged by kidneys Eg streptomycin, gentamicin
5
Q
Tetracyclines
4 things
A
Bacteriostatic
Inhibit protein synthesis
Accumulate in lungs
Eg oxytetracycline
6
Q
Macrolides
6things
A
Inhibits protein synthesis Narrow spec Poor GI tolerance Bacteriostatic (cidal at high concs) Time dependent Eg erythromycin
7
Q
Fluroquinilones
6things
A
Broad spec Inhibits DNA synthesis Concentration dependent Bactericidal Prolonged half life Eg enrofloxacin- baytril, marbofloxacin- marbocyl
8
Q
Metronidazole
5things
A
inhibits DNA synthesis Bactericidal Conc dependent Active against Protozoa and anaerobes Banned in food producing animals
