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Pharmacology > Respiratory > Flashcards

Flashcards in Respiratory Deck (14):
1

Physiological manipulation of bronchial diameter?

ANS-sym dilation- para constriction
Non adrenergic non cholinergicneres
Response to irritant receptors

2

Pharmacological manipulation of bronchial diameter

Autonomic agonists and antagonists
Drugs acting directly on smooth muscle

3

Adreno receptor agonists

Adrenaline, noradrenaline, ephedrine

Work fast system wide effects, all receptors, many side effects
Emergencies only

4

Selective adreno receptor agonists

b2 agonists
Terbutaline selective at low doses, high doses may stimulate tachycardia

Albuterol- topical, only one licensed

Clenbuteraol - oral, mainly horses

5

Adrenoreceptor antagonists

Beta blockers

6

Parasympathetic antagonists- anti cholinergics

Ipatropium
Topical
Increase bronchial diameter

7

Methylxanthines

Act directly on smooth muscle
Increase cAMP, relaxation, bronchodilator
Interferes with MLCK -- PDE inhibitors


Theophylline
Oral admin

8

What is an anti tussive?

Stops coughing reflex- vital defence mechanism so only when it is exhausting or damaging

9

Direct ant tussives?

Opioids - stops perceiving stimulus
Side effects? Can suppress other CNS functions

Eg butorphanol
Partial opioids agonist

10

Surfactants

Lower surface tension within the alveoli
Topical
Given to neonates in resp distress

11

Mucolytics

Makes mucous more runny

Bromohexine
Breaks down mucopolysaccahrides
Increases pulmonary alveolar permeability

12

Expectorants

Makes you cough things up
May or may not work
Irritate gastric mucosa

Eg potassium iodide

13

Decongestants

Reduce thickness of nasal mucosa

Sympathomimetics
Vasoconstriction of blood vessels in nasal mucosa
Topical nasal sprays

14

Doxapram

Respiratory stimulants
Increases chemoreceptors sensitivity
Increase RR and TV

may induce seizures