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Flashcards in Antibiotics Deck (28):
1

anaerobic coverage

metronidazole (flagyl) for gram negative
-below the diaphragm

Clindamycin for gram positive
-above the diaphragm

2

Side effect of zosyn

thrombocytopenia
monitor platelets on CBCs

3

Eagle Effect

Clindamycin can be used as an adjunct treatment in strep/staph infections, especially toxic shock
inactivates toxins

4

Goal blood concentration of antibiotics

4 times MIC

5

Penicillin coverage

Streptococcus
Sensitive Staph
Syphyllis

6

Amoxicillin coverage

PCN coverage (streptococcus, sensitive staph, syphyllis)
plus:
enterococcus
Haemophilus
some gram negatives

7

Unasyn (ampicillin/sulbactam) coverage

gram positive cocci
anaerobes
Some gram negatives
NO pseudomonas

8

Zosyn (piperacillin/tazobactam) coverage

gram positive cocci
anaerobes
Some gram negatives
Pseudomonas

No atypical, MRSA, VRE coverage

9

1st generation cephalosporins - Ancef (cefazolin), Keflex (cephalexin) coverage

gram positive cocci
Some gram negatives

10

Coverage for
2nd generation cephalosporins - cefuroxime, cefaclor, cefoxitin, cefprozil
3rd generation cephalosporins - ceftriaxone, cefdinir, cefixime, cefotaxime, cefpodoxime, ceftazidime (Fortaz), ceftibuten, ceftizoxime

gram positive cocci
expanded gram negative coverage

Fortaz (ceftazidime) - covers pseudomonas

11

4th generation cephalosporin - cefepime coverage

gram positive cocci
gram negative
has anti-pseudomonas coverage

12

Invanz (ertapenem) coverage

same as unsyn

gram positive cocci
anaerobes
Some gram negatives
NO pseudomonas

13

Imipenem, meropenem, doripenem coverage

same as zosyn

gram positive cocci
anaerobes
Some gram negatives
Pseudomonas

14

Aztreonam coverage

beta-lactam that does not have allergic cross reaction

covers gram negatives only

15

Macrolide coverage
-azithromycin, clarithromycin, erythromycin

General: gram positive cocci and upper respiratory gram negatives

Aerobic and anaerobic gram-positive cocci, except enterococci, MRSA, and some S. pneumoniae and S. pyogenes strains

Mycoplasma pneumoniae
Chlamydia trachomatis
Chlamydophila pneumoniae
Legionella sp
Corynebacterium diphtheriae
Campylobacter sp
Treponema pallidum
Propionibacterium acnes
Borrelia burgdorferi

16

Tetracycline coverage
-doxycycline
-tetracycline

covers gram positives including MRSA
anaerobes
gram negatives
chlamydia
rickettsia organisms (RMSF)

17

Quinolones - Avelox (moxifloxicin) coverage

gram positives, gram negatives, enterococcus, some TB coverage

18

Quinolones - Levaquin (levofloxacin) coverage

equal gram positive and gram negative coverage, pseudomonas coverage

19

Quinolones - Cipro (ciprofloxacin) coverage

gram negative, gram positive coverage
used for meningitis ppx
Pseudomonas

20

Aminoglycosides coverage
-gentamicin
-streptomycin
-amikacin, kanamycin, neomycin, tobramycin

gram negative coverage

21

Metronidazole coverage

anaerobic
gram negative

22

Vancomycin coverage (Firvanq, Vancocin)

gram positive coverage and MRSA

23

Daptomycin coverage (Cubicin)

Gram positive coverage, MRSA, VRE

24

Bactrim (TMP-SMX) coverage

gram positive, respiratory gram negatives
PCP coverage
MRSA coverage

Avoid use in soft tissue infections empirically, lacks Streptococcus coverage

25

Linezolid coverage (Zyvox)

gram positives, MRSA, VRE

26

MRSA coverage

Vancomycin
Daptomycin
Bactrim
Linezolid
Tetracyclines

27

VRE coverage

Daptomycin
Linezolid

28

Pseudomonas coverage

Zosyn
cefepime
Fortaz (ceftazidime)
Levaquin (levofloxacin)
Cipro (ciprofloxacin)