Antibiotics

Question 1

Bacterididal antibiotics (5)

Answer 1

Very Finely Proficient At Murder
Vancomycin
Fluoroquinolone
Penicillin
Aminoglycosides
Metronidazole

Question 2

Bacteriostatic antibiotics (6)

Answer 2

ECSTaTiC
Erythromycin
Clindamycin
Sulfamethoxazole

Timethoprim
Tetracycline
Chloraphenicol

Question 3

enzymatic hydrolysis of beta lactam ring by formation of beta-lactamases (penicillinases) is the mechanism of resistance of what

Answer 3

Staph aureus

tx: clavulanic acid, sulbactam, tazobactam

Question 4

structural changes in target PBPs is the mechanism of resistance of what

Answer 4

MRSA, pneumococci, enterococci

Question 5

changes in the porin structures in outer cell wall impeding access of penicillins to PBPs

Answer 5

Pseudomonas aeruginosa

Question 6

Renal tubular reabsorption inhibited by _____

Answer 6

Probenecid

Question 7

Long-acting intramuscular PCN preparations (2)

Answer 7

benzathine PCN, procaine penicillin

Question 8

Penicillins have increased activity against enterococci when combined with

Answer 8

aminoglycosides

Question 9

Antipseudomonal penicillins (3)

Answer 9

Takes Care of Pseudomonas
Ticarcillin
Carbenicillin
Piperacillin

Question 10

Cephalosporins are bactericidal, mostly IV, all have renal excretion EXCEPT ____ and _____

Answer 10

cefoperazone

ceftriaxone

Question 11

Microbes within the spectrum of activity of first generation cephalosporins

Answer 11

PEKs first
Proteus mirabilis
E. coli
K. pneumoniae

Question 12

First generation cephalosporins

Answer 12

FADer, help me FAZ my PHarmacology boards
CeFADroxil
CeFAZolin
CePHalothin
CePHaprin
CePHadrine
CePHalexin

Question 13

Microbes within the spectrum of activity of seccond generation cephalosporins

Answer 13

HEN PEKS
Haemophilus
Enterobacter aerogenes
Neisseria spp;

Proteus mirabilis
E. coli
K. pneumoniae
Serratia marcescens

Question 14

2nd generation cephalosporins

Answer 14

in a FAMily gathering, u see ur FOXy cousing wering a FUR coat and drinking TEA

ceFAMandole
ceFOXitin
ceFURoxime
cefoTEtan

FAC!  LORA the PROfessional AZhOLE is still on the FONe
ceFAClor
LORAcarbef
cefPROzil
cefmetAZOLE
ceFONicid

Question 15

Most active ceph against penicillin resistance Strep pneumoniae

Answer 15

Ceftriaxone

Cefotaxime

Question 16

3rd gen cephalosporins

Answer 16

FEnge PO ng PERA to FIX my TTTTTV
ceFEtamet
cefPOdoxime
cefoPERAzone
ceFIXime
cefTriaxone
cefTazidime
cefoTaxime
cefTizoxime
cefTibufen

Question 17

Drugs of last resort

Answer 17

I AM your Last Shot at Victory
imipenem
amikacin
meropenem
linezolid
streptogramins
vancomycin

Question 18

Bacterial Protein Synthesis Inhibitors

Answer 18

ATCELLS
aminoglycosides
tetracyclines
chloramphenicol
erythromycin (macrolides)
lincosamides (clindamycin)
linezolid
streptogramins

Question 19

anaerobic infections ABOVE the diaphragm

Answer 19

clindamycin

BELOW: metronidazole

Question 20

group of antibiotic that has concentration-dependent killing action

Answer 20

aminoglycosides

Question 21

time-dependent killing action

Answer 21

penicillins

cephalosporins

Question 22

killing action continues when their plasma levels declined below measurable levels

Answer 22

post-antibiotic effect (aminoglycosides)

Question 23

Most vestibulotoxic and nephrotoxic among aminoglycosides:

Answer 23

Gentamicin, tobramycin

Question 24

Most ototoxic aminoglycosides

Answer 24

kanamycin, amikacin

Question 25

neromuscular blockade side effect of aminoglycosides can be reversed by

Answer 25

calcium | Neostigmine

Question 26

most likely to produce skin reactions among aminoglycosides

Answer 26

neomycin | streptomycin

Question 27

weakly acidic compounds with a common chemical nucleus resembling PABA

Answer 27

Sulfonamides

Question 28

``` interferes with bacterial DNA synthesis by inhibiting: topoisomerase II (DNA gyrase) in G(-) organisms, prevents relaxation of supercoiled DNA ``` topoisomerase IV in G(+) organisms, interferes with the separation of repllicated chromosomal DNA during cell division

Answer 28

Quinolones

Question 29

1st generation fluoroquinolones and their spectrum of activity

Answer 29

Nalidixic acid, Cinoxacin, Rosoxacin, Oxolinic acid UTI

Question 30

2nd generation fluoroquinolones and their spectrum of activity

Answer 30

Ciprofloxacin, Ofloxacin, Norfloxacin, Lomefloxacin, Enoxacin G(-), gonococci, G(+), mycoplasma

Question 31

3rd generation fluoroquinolones and their spectrum of activity

Answer 31

Levofloxacin, Gemifloxacin, Moxiflixacin, Sparfloxacin, Grepafloxacin, Gatifloxacin, Pazufloxacin, Tosufloxacin, Balofloxacin Less G(-) and more G(+) activity, streptococci Enterococci

Question 32

4th generation fluoroquinolones and their spectrum of activity

Answer 32

Trovafloxacin, Alatrofloxacin, Prulifloxacin, Clinafloxacin broad spectrum, including anaerobes