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Antibiotics Flashcards

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1
Q

Penicillins MOA

A

Inhibition of cell wall synthesis

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2
Q

Penicillins cidal vs. static

A

cidal

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3
Q

Penicillins time vs. conc

A

Time dependent

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4
Q

Penicillins Spectrum

A

Naturals: G+, Staph, Anaerobic
Potentiated: G+, staph, G-, anaerobic, some also pseudamonas

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5
Q

Penicillins examples

A

Penicillin, diclocacillin, ampicillin, amoxicillin, amoxi/clav, ticarcillin, ticarcillin/clav

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6
Q

Carbapenems MOA

A

Inhibition of cell wall synthesis

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7
Q

Carbapenems cidal vs. static

A

cidal

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8
Q

Carbapenems time vs. conc

A

time

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9
Q

Carbapenems spectrum

A

Broad. G+, staph, G-, pseudamonas, anaerobic

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10
Q

Carbapenems examples

A

Meropenem, Imipenem

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11
Q

Cephalosporins 1st gen MOA

A

Inhibition of cell wall synthesis

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12
Q

Cephalosporins 1st gen cidal vs. static

A

cidal

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13
Q

Cephalosporins 1st gen time vs. conc

A

time

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14
Q

Cephalosporins 1st gen spectrum

A

G+&raquo_space; G-, staph, some anaerobes

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15
Q

Cephalosporins 1st gen examples

A

Cephalexin, Cefazolin

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16
Q

Cephalosporins 2nd gen MOA

A

Inhibition of cell wall synthesis

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17
Q

Cephalosporins 2nd gen cidal vs. static

A

cidal

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18
Q

Cephalosporins 2nd gen time vs. conc

A

time

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19
Q

Cephalosporins 2nd gen Spectrum

A

G+>G-, staph, good anaerobe, cefoxitin good for anaerobes

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20
Q

Cephalosporins 2nd gen examples

A

cefoxitin

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21
Q

Cephalosporins 3rd gen MOA

A

Inhibition of cell wall synthesis

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22
Q

Cephalosporins 3rd gen cical vs. static

A

cidal

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23
Q

Cephalosporins 3rd gen time vs. conc

A

time

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24
Q

Cephalosporins 3rd gen Sectrum

A

G+ < G-, staph not as good, good anaerobe

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25
Cephalosporins 3rd gen examples
Cefpodoxime, Cefovecin, etc
26
Fluoroquinolones MOA
Nucleic acid synthesis inhibitor - inhibits DNA gyrase and topoisomerase
27
Fluoroquinolones cidal vs. static
cidal
28
Fluoroquinolones time vs. conc
conc
29
Fluoroquinolones spectrum
Excellent G-, Good G+, Staph, weak anaerobes
30
Fluoroquinolones examples
Enrofloxacin, marbofloxacin, prado, orbi, etc
31
Glycopeptides MOA
Inhibits cell wall synthesis
32
Glycopeptides cidal vs. static
cidal
33
Glycopeptides time vs. conc
time
34
Glycopeptides spectrum
G+ only, staph, anaerobes
35
Glycopeptides examples
Vancomycin
36
Lincosamides MOA
Inhibits protein synthesis - binds 50s ribosome
37
Lincosamides cidal vs. static
static (Cidal at high pH)
38
Lincosamides time vs. conc
time
39
Lincosamides spectrum
Excellent G+ and anaerobes, staph, minimal G-
40
Lincosamides examples
Clindamycin, lincosamycin
41
Chloramphenicol MOA
Inhibits protein synthesis - binds 50s ribosome
42
Chloramphenicol cidal vs. static
static
43
Chloramphenicol time vs. conc
time
44
Chloramphenicol spectrum
Good G+, moderate G-, excellent anaerobes
45
Chloramphenicol examples
...Chloramphenicol
46
Macrolides MOA
Inhibits protein synthesis - binds 50s ribosome
47
Macrolides cidal vs. static
static
48
Macrolides time vs. conc
time
49
Macrolides spectrum
Excellent G+, staph, good anaerobes, Some G- (azithro more than erythro)
50
Macrolides examples
erythromycin, azithromycin
51
Metronidazole MOA
Inhibits nucleic acid synthesis
52
Metronidazole cidal vs. static
cidal
53
Metronidazole time vs. conc
conc
54
Metronidazole spectrum
Excellent anaerobes
55
Metronidazole examples
really???
56
Tetracyclines MOA
Inhibits protein synthesis - binds 30s ribosome
57
Tetracyclines cidal vs. static
static
58
Tetracyclines time vs. conc
time
59
Tetracyclines spectrum
G+, staph, G-, anaerobes
60
Tetracyclines examples
Doxycycline, minocycline
61
Tetracyclines special facts
esphageal stricture
62
Aminoglycosides MOA
Inhibits protein synthesis - binds 30s ribosome (maybe 50s too per Boothe?)
63
Aminoglycosides cidal vs. static
cidal
64
Aminoglycosides time vs. conc
conc
65
Aminoglycosides spectrum
G-, staph, pseudomonas
66
Aminoglycosides examples
Gentamicin, amikacin, neomycin
67
Aminoglycosides special facts
Nephrotoxic, ototoxicity
68
Sulfa drugs MOA
Blocs folic acid synthesis Sulfadiazine - inhibits folic acid synthetase Trimethoprim 0 inhibits folic acid reductase
69
Sulfa drugs cidal vs. static
Sulfa alone - static | TMS - cidal
70
Sulfa drugs time vs. conc
Time
71
Sulfa drugs Spectrum
G+, G-, staph, anaerobic
72
Sulfa drugs examples
TMS
73
Sulfa drugs special facts
Can cause KCS Dobermans hypersensitive Can cause immune diseases
74
Rifampin MOA
Inhibits RNA synthesis
75
Rifampin cidal vs. static
cidal
76
Rifampin time vs. conc
conc
77
Rifampin spectrum
G+, staph, anaerobes
78
Rifampin examples
rifampin. yup.
79
Rifampin special facts
Orange urine, rapid development of resistance

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