Chemo drugs Flashcards
1
Q
Alkylating agents MOA
A
- non-cell cysle-specific
- insert alkyl groups into DNA/RNA strands, interfering in DNA and RNA replication
2
Q
Alkylating agents disadvantages
A
- hepatic toxicity in 6% of patients
- Metabolite (acrolein) renally excreted - can cause sterile hemorrhagic cystitis - give with furosemide
3
Q
Alkylating agents example
A
- Cyclophosphamide
- Lomustine
4
Q
Cyclophosphamide
A
- Alkylating agent
- part of CHOP for lymphoma
5
Q
Lomustine
A
- Alkalating agent
- MCT (alone or with vinblastine) and histiocystic sarcoma, rescue agent for lymphoma
6
Q
Drugs in CHOP
A
- C = cyclophosphamide
- H = hydroxydaunorubicin/doxorubicin
- O = oncovin (vincristine)
- P = prednisone/prednisolone
7
Q
Vinca alkaloids MOA
A
- cell cycle specific
- microtubule inhibitors that affect the spindle apparatus during mytosis
- metablized in the liver and ecreted in the feces
8
Q
Vinca alkaloids side effects
A
- minimally myelosuppressive
- paralytic ileus seen with vincristine
- extravasation-related phlebitis and tissue damage
9
Q
Vinca alkaloids examples
A
- vincristine
- vinblastine
- vinorelbine
10
Q
Vincristine
A
- vinca alkaloid
- part of CHOP (oncovin)
11
Q
Vinblastine
A
- vinca alkaloid
- MCT (+/- with lomustine)
12
Q
Vinorelbine
A
- Vinca alkaloid
- rescue agent for lymphoma and MCT
- primary lung tumors
13
Q
Antitumor antibiotics MOA
A
- Non-cell cycle specific
- Multiple
- topoisomerase inhibitions, DNA intercalation, formation of iron-mediated free radicals that lead to DNA damage
- metabolized by the liver and eliminated in the feces
14
Q
Antitumor antibiotics disadvantages
A
- DCM-like damage with cumulative dosages >180-240mg/m2
- severe vesicant with extravasation
- renal insufficiency in cats
- significant myelosuppression and GI toxicity
15
Q
Antitumor antibiotics examples
A
- Doxorubicin
