ANTIBIOTICS - ANTIPROTOZOAL

Question 1

examples of TISSUE SCHIZONTICIDES (kill schizonts in the liver)

Answer 1

primaquine, atovaquone

Question 2

examples of BLOOD SCHIZONTICIDES

Answer 2

chloroquine, quinine mefloquine, atovaquone, pyrimethamine, doxycycline, halofantrine, artemisinin

Question 3

example of GAMETOCIDES

Answer 3

primaquine

Question 4

examples of SPORONTICIDES (prevent sporogony and multiplication in the mosquito)

Answer 4

proguanil, pyrimethamine

Question 5

Side effect include Cinchonism (headache, tinnitus, vertigo), Hemolysis in G6PD deficiency, Blackwater fever

Answer 5

QUININE

QUINIDINE GLUCONATE

Question 6

DOC for malaria in pregnant patients

Answer 6

Quinine

Question 7

• severe complication of P. falciparum malaria
• characterized by intravascular hemolysis, massive hemoglobinuria and acute renal failure

Answer 7

Blackwater fever

Question 8

radical cure of P. vivax, P. ovale

Terminal prophylaxis (vivax, ovale)

Answer 8

PRIMAQUINE

Question 9

Treatment and chemoprophylaxis (chloroquine-resistant P.falciparum) - all stages

Answer 9

ATOVAQUONE-PROGUANIL

Question 10

Common side effect is a headache without organic lesion that is Pseudotumor cerebri.

Answer 10

Doxycycline

Question 11

Forms toxic free radicals in malarial food vacuole. Blood schizonticide.

Answer 11

ARTEMISININ

ARTESUNATE, ARTEMETHER, DIHYDROARTEMISININ

Question 12

the drug of choice for uncomplicated falciparum malaria in the Philippines

Answer 12

Artemether-Lumefantrine (Co-Artem)

Question 14

DOC for Chloroquine sensitive P. falciparum

Answer 14

Chloroquine

Question 15

DOC for P. vivax and P. ovale

Answer 15

Chloroquine then Primaquine

Question 16

examples of TISSUE AMEBICIDES (act on organisms in the bowel wall and the liver)

Answer 16

chloroquine, emetines, metronidazole, tinidazole

Question 17

examples of LUMINAL AMEBICIDES (act only in the lumen of the bowel)

Answer 17

diloxanide furoate, iodoquinol, paromomycin

Question 18

Asymptomatic cyst carriers of E. histolytica (drug of choice)

Answer 18

DILOXANIDE FUROATE

Question 19

used for Severe intestinal and extraintestinal amebiasis (drug of choice), Trichomoniasis, Giardiasis, Bacterial vaginosis, Anaerobic infections (B. fragilis, C. difficile), Peptic ulcer disease

Answer 19

Metronidazole

Question 20

DOC for Cryptosporidiosis

Answer 20

NITAZOXANIDE

Question 21

Prophylaxis and treatment of pneumocystosis (drug of choice), Prophylaxis (T. gondii, I. belli)

Answer 21

CO-TRIMOXAZOLE

Question 22

Prophylaxis and treatment of Toxoplasmosis (drug of choice)

Answer 22

SULFADIAZINE-PYRIMETHAMINE

Question 23

Advanced West African sleeping sickness (drug of choice)

Answer 23

EFLORNITHINE

Question 24

African sleeping sickness (drug of choice)

Answer 24

MELARSOPROL

Question 25

**Chagas disease** (drug of choice),

Answer 25

NIFURTIMOX

Question 26

**Leishmaniasis** (drug of choice except in India)

Answer 26

SODIUM STIBOGLUCONATE

Question 27

**Whipworm infections** (drug of choice),

Answer 27

MEBENDAZOLE

Question 28

**Trichinosis** (drug of choice),

Answer 28

THIABENDAZOLE

Question 29

**Filariasis** (drug of choice), **Eye worm disease** (drug of choice),

Answer 29

DIETHYLCARBAMAZINE

Question 31

May cause **Mazzotti reaction** when used for onchocerciasis

Answer 31

DIETHYLCARBAMAZINE

Question 32

**Strongyloidiasis** (drug of choice),

Answer 32

IVERMECTIN

Question 33

can cause **Mazzoti reaction** (fever, headache, dizziness, rashes, pruritus, tachycardia, hypotension, pain in joints, muscles and lymph glands),

Answer 33

IVERMECTIN

Question 34

**Ascaris, Hookworm and Pinworm infections** (drug of choice),

Answer 34

PYRANTEL PAMOATE

Question 35

**Ascariasis, Hookworm, Pinworm, Hydatid disease** (drug of choice), Whipworm infections, Cutaneous & Visceral Larva migrans, Cysticercosis (larval stages of T. solium), Angiostrongylus cantonensis, Capillaria philippinensis

Answer 35

ALBENDAZOLE

Question 36

Drug of choice for **trematodes / flukes** (Schistosoma, Paragonimus, Clonorchis, Opisthorchis, Fasciolopsis, Heterophyes) and **cestodes / tapeworms** (Taenia, Diphyllobothrium, Hymenolepsis)

Answer 36

PRAZIQUANTEL

Question 37

Prazaquantel is the DOC of flukes except **Fasciola hepatica.** What is its DOC?

Answer 37

bithionol or triclabendazole

Question 38

Ivermectin is the DOC for ____ and \_\_\_\_\_

Answer 38

STRONGYLOIDES AND ONCOCERCA VOLVULUS