Antibiotics + Misc. Drugs

Question 1

What drugs bind to trans peptides’ e-binding protein and inhibits transpeptidase cross-linking of the peptidoglycan on the cell wall?

Answer 1

• Penicillins
• Cephalosporins

Question 2

What drug binds to penicillin-binding protein 3 and inhibits peptidoglycan cross-linking?

Answer 2

• Beta - lactams (aztreonam)

Question 3

What drug inhibits the cell wall peptidoglycan formation by binding to D-ala-D-ala?

Answer 3

Vancomycin

Question 4

What drug inhibits the initiation complex by binding to 30s subunit?

Answer 4

• Aminoglycosides
• Tetracyclines

Question 5

What drug inhibits the initiation complex by binding to 50s subunit?

Answer 5

Linezolid

Question 6

What drug inhibits peptidyl transferase by binding to 50s Subunit?

Answer 6

Chloramphenicol

Question 7

What drug inhibits peptide transfer by binding to 50s subunit?

Answer 7

Clindamycin

meaning it inhibits translocation

Question 8

What drug prevents the attachment of aminoacyl tRNA?

Answer 8

Tetracyclines

Question 9

What drug binds to 23s rRNA of the 50S subunit and inhibits protein synthesis?

Answer 9

Macrolides

Question 10

What two antibiotics bind to cell membranes and cause cell membrane disintegrity?

Answer 10

• Daptomycin
• Polymyxins

Question 11

Anti fungal that binds to ergosterol and causes cell membrane disintegrity?

Answer 11

Amphotericin B

Question 12

Which antibiotic damages DNA by forming free radicals?

Answer 12

Metronidazole

Question 13

Which antibiotic is a partial monoamine oxidase inhibitor?

Answer 13

Linezolid

can cause Serotonin Syndrome

Question 14

Which antibiotic inhibits dihydropteroate synthase and inhibits folic acid synthesis?

Answer 14

Sulfonamides (SMX, Dapsone)

Question 15

Which antibiotic inhibits dihydrofolate reductase?

Answer 15

TMP

Question 16

Reversal drug for Dapsone Toxicity

Answer 16

Methylene Blue

Question 17

Which antibiotic inhibits arabinosyltransferase?

Answer 17

Ethambutol

Question 18

What is a side effect of ethambutol?

Answer 18

optic neuritis

Question 19

What drug inhibits DNA-dependent RNA polymerase?

Answer 19

Rifampin

Question 20

What antibiotic can cause red/orange secretions and hepatotoxicity?

Answer 20

Rifampin

Question 21

Which antibiotic is activated by KatG?

Answer 21

Isoniazid

Question 22

What is a major side effect of Isoniazid?

Answer 22

Drug-Induced Lupus

(HIPPE - drug induced lupus drugs)

Question 23

Which antifungal agent inhibits the conversion of Lanosterol to ergosterol?

Answer 23

• azoles

Question 24

What antifungal agent inhibits squalene epoxidase?

Answer 24

Terbinafine

Question 25

Which antifungal inhibits microtubule polymerization?

Answer 25

Griseofulvin

Question 26

Which antifungal agent inhibits DNA and RNA synthesis?

Answer 26

Flucytosine

Question 27

MOA of Mebendazole

Answer 27

Microtubule inhibitor

Question 28

Which antifungal agent is a cell wall inhibitor?

Answer 28

Caspofungin

Question 29

What drugs inhibit viral DNA polymerase and causes DNA chain termination?

Answer 29

- Acyclovir - Ganciclovir - Cidofovir

Question 30

What drug inhibits the interaction with gp120?

Answer 30

Maraviroc

Question 31

What drug binds to gp41 and inhibits fusion of the HIV virus?

Answer 31

Enfuviritide

Question 32

What is a SE of acyclovir?

Answer 32

crystalline nephropathy

Question 33

MOA of Raltegravir

Answer 33

HIV integrase Inhibitor