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Flashcards in Antibiotics: More Deck (12):
1

What is the activity of cefepime?

broad gram pos and gram negative activity including against enterobacter and pseudomonas

2

How can I recognize third generation cephalosporins?

often have t: cephotaxime, ceftriaxone, ceftazidime (though many 2nd gen cephalosporins do too)

3

What monobactam should I know?

aztreonam

4

Use of aztreonam?

aerobic gram neg rods: Pseudomonas
distributes to CNS. not cross-allergenic with other beta lactams

5

What are carbapenems?

beta lactams but they have different stereochemistry in the beta lactam ring so tend to be resistant to beta lactamases
broad spectrum- gram pos, most gram neg rods, anaerobes. not MRSA, C diff, legionella

6

Vancomycin: MoA

binds termal D-ala d alal of peptide chane. causes steric bulk that inhibits transglycosylase: not elongation of the peptidoglycan

7

Vancomycin: spectrum

only gram positive: too big to penetrate the outer membrane of gram negatives.

8

What toxicities are associated with vancomycin?

ototoxicity, nephrotoxicity, skin flushing

9

What is telavancin?

vancomycin derivative with a longer half life

10

Daptomycin: MoA

pore-forming membrane lytic molecule.

11

Daptomycin: activity

gram positives- including MRSA and VRSA

12

What toxicities are associated with daptomycin?

myopathy, allergy pnemonitis.
antagonized by interaction with pulmonary surfactant.
DON'T USE TO TREAT PNEUMONIA