Flashcards in Autacoids drugs Deck (14):
What is the target of the triptans? What do they treat? MoA?
MoA unclear- may cause selective vasoconstriction that reduces pain
What drugs target 5HT3 receptors? uses, names, agonist/antagonist?
anti-emesis drugs are 5HT3 antagonists.
Examples are ondansetron, granisetron
What is sumatriptan?
5HT1 agonist. treats migranes
What is fluoxetine?
prozac: selective seratonin reuptake inhibitor- targers serotonin reuptake transporter.
What is ondasetron? What is granisetron?
5-HT-3 receptor antagonists used as anti-emetics during chemo?
What is the role of organic bases in terms of histamine?
organic bases are used in many drugs to stimulate histamine release from mast cells
What should I know about epinephrine and histamine?
epinephrine acts on beta receptors to inhibit histamine release from mast cells
inhibits histamine release from mast cells.
What works on mast cells to inhibit histamine release?
epinephrine and cromolyn sodium
What are first generation H1 blockers and their use? Side effects?
used to treat allergic reactions
chlorpheniramine and diphenhydramine
CNS side effects like drowsiness and antimuscarininc properties
What are second generation H1 blockers and their use? Sides>
Early second generation H1 blockers have been taken off the market due to cardiac arrhythmia side effects.
Recent 2nd generation drugs- loratradine (claritin)
don't have CNS effects b/c don't cross blood/brain barrier.
What are the pharmacological properties of H1 blockers? (what do they do to the body)
-antagonize rapid onset, transient vasodilation
-inhitib capillary permeability and edema at site of inflammation
-inhibit pain/itching at site of injury
-CNS depression in first generation
-Antimuscarinic effects in first generation
-inhibit motion sickenss from antimuscarinic properties (dimenhydrinate/dramaine)
What are H2 receptor antagonists? uses?
and famotidine (Pepcid)
proton pump inhibitors that treat stomach ulcers and GERD. inhibit volume and H+ concentration of secreted acid.