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Pharmacology 119 Test # 2 > Antibiotics Part 2 > Flashcards

Flashcards in Antibiotics Part 2 Deck (13)
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(T/F) Aminoglycosides are not given orally. Why or why not?

True - They have poor oral absorption


What trough level is associated with a risk for ototoxicity and nephrotoxicity when taking Aminoglycosides?

trough levels greater than 2mcg/mL often manifests as some degree of temporary or permanent hearing loss and reduced renal function.


Explain the synergistic effect when administering aminoglycosides with beta-lactam antibiotics.

When aminoglycosides are used in combination with beta-lactam antibiotics, the beta-lactam antibiotic should be given first because they break down the cell wall of the bacteria and allow the aminoglycoside to gain access to the ribosomes where they work.


What are the indications for the use of Aminoglyocides?

1) Prophylaxis in GI and GU procedures
2) Valvular heart disease


What are some of the common adverse effects of Amoniglycosides?

1) Nephrotoxicity (manifests as ⬆ BUN and ⬆ serum creatinine levels).
2) Ototoxicity (manifests as hearing and balance loss).
3) Dizziness
4) Tinnitus
5) Feelings of fullness in the ears
6) Paresthesia
7) Vertigo
8) Skin Rash


What are some of the indications for the use of Quinolones?

1) UTIs
2) Respiratory infection
3) Skin infection
4) Bone infection
5) GI infection
6) Joint infection
7) STDs


Why is the use of Quinolones in prepubescent children not generally recommended?

Because these drugs have been shown to affect cartillage development in laboratory animals.


What is the major adverse effect of Quinolones which caused a black box warning label to be issued by the FDA?

Tendonitis and ruptured tendons


When is the preferred dosing time of Quinolones?

2 hours after meals


Why should patients not take antacids at the same time as oral Quinolones?

Antacids prevent the inactivation of the antibiotic.


What types of foods increase the risk of crystalluria in patients taking Quinolones and what can be done to prevent it

1) Dairy foods, peanuts, sodium bicarbonate
2) Forcing fluids and increased intake of of foods high in ascorbic acid (i.e., cranberry and citrus juices).


(T/F) Patient's taking Quinolones should avoid exposure to sun and tanning beds.

True - Use sun glasses and sun screen for protection.


When should patient's take calcium and magnesium during quinolone therapy?

At least one hour before or after