antibodies, immunodiagnosis and immunotherapy Flashcards
(14 cards)
what is the major serum antibody?
IgG
is serum IgA pro-inflammatory or non-inflammatory?
pro-inflammatory
which is the predominant mucosal Ig?
IgA2 (Secretory IgA)
which Ig has low affinity and high avidity?
IgM
which Ig can cross placenta?
IgG
which Ig causes allergy and is highly specialised in helminth infections?
IgE
which Ig is receptor of naive B cells?
monomeric IgM
which Ig is mostly found on surface of mast cells, eosinophils and basophils in complex with Fc receptor?
IgE
does IgG have high or low affinity?
high affinity
which type of diagnostic test does Coomb’s test fall under?
a. precipitation-based
b. agglutination-based
c. ELISA
b. agglutination-based
precipitation-based
- turbidimetry (measured in fluids)
- Nephelometry (measured in fluids)
- Immunodiffusion (measured in media or gel)
what does Direct Coomb’s test test for?
autoimmune haemolytic anaemia
antibody response to bacterial infection is usually:
a. monoclonal
b. polyclonal
c. mixture of both
d. starts as monoclonal and then switches to polyclonal
b. polyclonal
recognise different antigens on infective agent (multiple epitopes of same antigen)
which protein is a T-cell inhibitor that is expressed by cancer cells?
a. CD20
b. tumour necrosis factor
c. CTLA-4
d. PD-1
CTLA-4 and PD-1
Mechanisms by which tumours are able to evade the immune system include:
A. the acquisition of limitless replicative potential
B. the expression of immunoregulatory cytokines IL-10 and TGFβ
C. the expression of mutated oncogenes
D. the expression of the immunoregulatory cytokines IL-10 and TNF
E. the upregulation of MHC class I
B. the expression of immunoregulatory cytokines IL-10 and TGFβ
promote infiltration of Tregs –> inhibit anti-tumour CTLs
