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Anticancer and Immuno Flashcards

1
Q

Recombinant interferon- (IFN-) is the currently approved therapy for patients who are chronically infected with hepatitis B virus (HBV) or hepatitis C virus (HCV). IFN was originally described in chicken embryo cells infected with influenza viruses. Which of the following statements best describes IFN’s suspected mode of action as an antiviral reagent?

A. It stimulates a cell-mediated immunity
B. It stimulates humoral immunity
C. Its direct antiviral action is related to the suppression of messenger RNA formation
D. Its action is related to the synthesis of a protein that inhibits translation or transcription
E. It alters the permeability of the cell membrane so that viruses cannot enter the cell

A

D. Its action is related to the synthesis of a protein that inhibits translation or transcription

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2
Q

Allopurinol is potentially dangerous if used in combination with mercaptopurine because of:

A. Inhibition of hypoxanthine-guanine phosphoribosyl-transferase
B. Inhibition of xanthine oxidase
C. Inhibition of guanylate kinase
D. Accumulation of the chemotherapeutic agent

A.  A, B, C
B.  A, C
C.  B, D
D.  D only
E.  All of the Above
A

C. B, D

B. Inhibition of xanthine oxidase & D. Accumulation of the chemotherapeutic agent

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3
Q

Cyclophosphamide,cisplatin, busulfan, and Procarbazine all have in common the classification of:

A. Antimetabolite
B. Antibiotic
C. Alkylating agent
D. Intercalator
E. All of the Above
A

C. Alkylating agent

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4
Q

Hemorrhagic cystitis is associated with:

 A. dacarbazine
 B.  methotrexate
 C.  cisplatin
 D.  cyclophosphamide
A.  A, B, C
B.  A, C
C.  B, D
D.  D only
E.  All of the Above
A

D. D only

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5
Q

While reviewing charts in a general medicine clinic you see that a patient, 55-years-old and with no history of cancer at all, is taking methotrexate. What is the most likely condition for which this “anticancer drug” is being given?

A. Asthma or emphysema
B. Hyperthyroidism
C. Hyperuricemia or clinical gout
D. Myasthenia gravis
E. Rheumatoid arthritis or psoriasis
A

E. Rheumatoid arthritis or psoriasis

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6
Q

A middle-aged anatomy professor attends the hottest Indianapolis 500 race in decades and sits with the sun facing him; there is no breeze. He has a history of borderline high uric acid. Dehydration during the race triggers uric acid crystal formation in his foot. The foot becomes sore, red, hot, and swollen. He drinks about 2 L of water and soda at the race and two more liters at home. However, he is anuric for 10 to 12 hours. His physician prescribes colchicine as an anti-inflammatory. A metaphase-blocking dose of colchicine functions through which one of the following mechanisms?

A. Depolymerization of actin
B. Depolymerization of myosin
C. Enhancement of tubulin polymerization
D. Inhibition of tubulin polymerization
E. Binding to and stabilizing microtubules
A

D. Inhibition of tubulin polymerization

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7
Q

Congestive heart failure is associated with:

A. Cyclophosphamide
B. L-asparaginase
C. Cisplatin
D. Doxorubicin
E. Vincristine
A

D. Doxorubicin

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8
Q

Anti cancer drug associated with Pulmonary fibrosis is

A. Cisplatin
B. Asparginase
C. Bleomycin
D. Cyclophosphamide
E. Methotrexate
A

C. Bleomycin

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9
Q

Anti cancer drug associated with pancreatitis is

A. Methotrexate
B. Asparginase
C. Cisplatin
D. Bleomycin
E. Doxorubicin
A

B. Asparginase

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10
Q

Anticancer Drug that inhibits microtubular polymerization

A. Cisplatin
B. Doxorubicin
C. Vincristine
D. 6-Mercaptopurine
E. Methotrexate
A

C. Vincristine

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11
Q

One of the following Anti cancer Drugs is combined with Mesna

A. Cisplatin
B. Bleomycin
C. Doxorubicin
D. Cyclophosphamide
E. Procarbazine
A

D. Cyclophosphamide

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12
Q

The Monoclonal Antibody used in Crohn’s Disease and RA is

A. Abciximab
B. Dacliximab
C. Infliximab
D. Muronomab
E. Palivizumab
A

C. Infliximab

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13
Q

The Monoclonal Antibody used in Respiratory syncyntial virus which blocks RSV protein is

A. Abciximab
B. Dacliximab
C. Infliximab
D. Muronomab
E. Palivizumab
A

E. Palivizumab

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14
Q

The Monoclonal Antibody used in kidney transplants which blocks IL-2 receptors is

A. Abciximab
B. Dacliximab
C. Infliximab
D. Muronomab
E. Palivizumab
A

B. Dacliximab

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15
Q

The cytokine which is used in Multiple sclerosis is

A. Interleukin-11
B. Interferon-Alpha
C. Interferon-Beta
D. Interferon-Gamma
E. Aldesleukin
A

C. Interferon-Beta

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16
Q

The cytokine which is used in Chronic Granulomatous Disease is

A. Interleukin-11
B. Interferon-Alpha
C. Interferon-Beta
D. Interferon-Gamma
E. Aldesleukin
A

D. Interferon-Gamma

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17
Q

The cytokine which is used in Hepatitis B and C infections is

A. Interleukin-11
B. Interferon-Alpha
C. Interferon-Beta
D. Interferon-Gamma
E. Aldesleukin
A

B. Interferon-Alpha

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18
Q

Antidote for the patient coming to the ER with Rice water stools,Seizures,Garlic breath is

A. Desferroxamine
B. Succimer
C. Dimercaprol
D. Penicillamine
E. All of the above
A

C. Dimercaprol

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19
Q

Nephropathy,Wrist drop,Hepatitis and Anaemia are classical features of one of the following Heavy metal poisoning

A. Lead
B. Mercury
C. Iron
D. Arsenic
E. All of the above
A

A. Lead

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20
Q

A 26-year-old man is taken to the emergency department by his roommate. The patient is comatose and has nonreactive pinpoint pupils, respirations are 5/min, and blood pressure is 80/40 mm Hg. Physical examination shows needle tracks on the patient’s arms, and the roommate reports finding a needle and syringe lying next to the patient. What is the most appropriate agent for the emergency management of this patient?

A. acetylcysteine
B. activated charcoal
C. flumazenil
D. naloxone
E. pentazocine
A

D. naloxone

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21
Q

Antidote for copper poisoning is

A. Desferroxamine
B. Succimer
C. Dimercaprol
D. Penicillamine
E. All of the above
A

D. Penicillamine

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22
Q

Bleomycin is specific to which phase of the cell cycle?

A. G0 phase
B. G2 phase
C. M phase
D. S phase
E. All of the above
A

B. G2 phase

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23
Q

One of the following Anti cancer drugs is specific to S phase of the cell cycle

A. Vincristine
B. Bleomycin
C. Methotrexate
D. Cisplatin
E. Dacarbazine
A

C. Methotrexate

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24
Q

Neutropenia develops in a patient undergoing cancer chemotherapy. Administration of which one of the following agents would accelerate recovery of neutrophil counts?

A. Leucovorin
B. Filgrastim
C. Prednisone
D. Vitamin B12
E. Folic acid
A

B. Filgrastim

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25
Q

Hydration and/or diuresis can prevent the renal toxicity associated with:

A. cisplatin.
B. chlorambucil.
C. tamoxifen.
D. gemcitabine.
E. methotrexate.
A

A. cisplatin.

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26
Q

A patient is being treated with allopurinol to control hyperuricemia resulting from chemotherapy Which of the following would have to have its dose reduced to prevent toxicity?

A. 5-Fluorouracil
B. 6-Mercaptopurine
C. 6-Thioguanine
D. Fludarabine
E. Cytarabine
A

B. 6-Mercaptopurine

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27
Q

Your patient developed acute poisoning as a result of inhaling cyanide gas in an industrial accident. In addition to providing symptomatic, supportive care, and other appropriate interventions, administering which of the following would be the most likely to play a crucial role in treating the cyanide poisoning?

A. Ammonium chloride
B. Deferoxamine
C. Dimercaprol (BAL; British anti-Lewisite)
D. N-acetylcysteine
E. Pralidoxime
F. Sodium thiosulfate
A

F. Sodium thiosulfate

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28
Q

A 15-year-old boy attempts suicide with a liquid that he found in his parents’ greenhouse. His dad used it to broken first of “varmints” around the yard. The toxin causes intense abdominal pain, skeletal muscle cramps, projectile vomiting, and severe diarrhea that leads to fluid and electrolyte imbalances, hypotension, and difficulty swallowing. On examination he is found to be volume depleted and is showing signs of a reduced level of consciousness. His breath smells “metallic.” Which of the following probably accounts for these symptoms?

A.Arsenic
B. Cadmium
C. Iron
D. Lead
E. Zinc
A

A.Arsenic

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29
Q

A 26 year old male presents with testicular cancer and chemotherapy with cisplatin is initiated. Which agent is most likely to be useful to control the severe nausea and emesis associated with the use of this drug:

A. Meclazine
B. Dexamethasone
C. Cyproheptadine
D. Ondansetron
E. Promethazine
A

D. Ondansetron

30
Q

A patient has completed a course of cancer chemotherapy and now has severe anemia, neutropenia, and thrombocytopenia. If only one intervention is possible, which of the following is the most appropriate therapy?

A. epoetin
B. filgrastim
C. growth hormone
D. sargramostim
E. testosterone
A

D. sargramostim

31
Q

As part of the treatment plan for the Hodgkin’s patient described in the previous question, we have given mechlorethamine. Which of the following statements best describes the anticancer mechanism of action of this drug?

A. Alkylates DNA, causing cross-links between parallel DNA strands
B. Blocks microtubular assembly and mitosis during M-phase
C. Inhibits topoisomerase, preventing repair of DNA strand breaks
D. Intercalates in DNA strands, thereby preventing DNA replication by mRNA
E. Stabilizes microtubular arrays, thereby preventing mitosis

A

A. Alkylates DNA, causing cross-links between parallel DNA strands

32
Q

Our patient has advanced Hodgkin’s disease. One of the drugs we administer is vincristine, as part of the so-called MOPP regimen (vincristine, mechlorethamine, procarbazine, and prednisone).Which of the following is the most likely mechanism by which the vincristine is exerting its intended cytotoxic effects?

A. Alkylates DNA, causing cross-links between parallel DNA strands
B. Blocks microtubular assembly and mitosis during M-phase
C. Inhibits topoisomerase, preventing repair of DNA strand breaks
D. Intercalates in DNA strands, thereby preventing DNA replication by mRNA
E. Stabilizes microtubular arrays, thereby preventing mitosis

A

B. Blocks microtubular assembly and mitosis during M-phase

33
Q

A 60-year-old man has been using a kerosene space heater and candles to keep warm in the winter. He is transported to the hospital with complaints of severe headaches, nausea, dizziness, and a diminution in vision. He has a decreased arterial blood oxygen (O2)-carrying capacity, but no change of his arterial Po2. Which of the following most likely accounts for these findings?

A.Carbon monoxide (CO)
B. Methane
C. Nitrogen dioxide
D. Ozone
E. Sulfur dioxide
A

A.Carbon monoxide (CO)

34
Q

We have just confirmed that our patient is pregnant, and give her a strong warning to avoid taking supplements of a vitamin, especially in high doses, because the substance is highly teratogenic. We also avoid administering any drugs that are derivatives of this nutrient during pregnancy, for the same reason. To which of the following vitamins does this precaution apply?

A. A
B. B12
C. C
D. E
E. Folic acid
A

A. A

35
Q 
Which of the following is recommended for treating hairy cell leukemia?
A. Methotrexate
B. cladribine
C. vinblastine
D. cytarabine
E. Cyclophosphamide
A

B. cladribine

36
Q 
Which of the following is a Folic acid antagonist: binds to catalytic site of dihydrofolate reductase-
A. altretamine
B. cisplatin
C. Methotrexate
D. fludarabine
E. Vinblastine
A

C. Methotrexate

37
Q 
Which of the following is the pyrimidine analog is used systemically to treat adenocarcinomas, topically for skin cancer and works through inhibition of DNA synthesis.
A. cytarabine
B. vinblastine
C. fluorouracil (5-FU)
D. cladribine (Leustatin)
E. vincristine
A

C. fluorouracil (5-FU)

38
Q 
Administration of this plant alkaloid anticancer agent is associated with significant incidence of neurotoxicity.
A. topotecan 
B. vincristine (Oncovin)
C. vinblastine
D. prednisone
E. None of the above
A

B. vincristine (Oncovin)

39
Q 
Which of the following anticancer drug acts on osteoclasts to decrease serum calcium levels (independent of its antitumor action) ?
A. dactinomycin
B. doxorubicin (Adriamycin)
C. bleomycin
D. plicamycin (Mithramycin)
E. Methotrexate
A

D. plicamycin (Mithramycin)

40
Q

Gingivitis, discolored gums and loose teeth and auditory and visual loss are common symptoms of chronic exposure to this agent.

A. Mercury
B. Lead
C. Iron
D. Trivalent arsenic
E. Succimer
A

A. Mercury

41
Q

A 39-year-old man visits an occupational health clinic because of insomnia, memory loss, irritability, depression, shyness, and tremor. Additional findings include mild symptoms of gingivitis, stomatitis, and excess salivation. Which of the following parenteral chelators would be the most effective in treating the severe metal poisoning in this patient?

A.Deferoxamine
B.Dimercaprol
C.Edetate calcium disodium
D.Penicillamine
E.Succimer
A

B.Dimercaprol

42
Q

A 29-year-old couple who have recently moved into an old, deserted farmhouse and are renovating it complain of weakness and lethargy, which have become progressively worse during the past few months. Both show signs of ataxia. Blood studies show anemia and elevated levels of free erythrocyte protoporphyrin. These patients have most likely been exposed to

A.hantavirus
B.lead
C.manganese
D.mercury
E.thallium
A

B.lead

43
Q

A 68-year-old woman undergoes surgery for stage III colorectal adenocarcinoma with involvement of regional lymph nodes. She is subsequently treated with irinotecan in combination with fluorouracil (5-FU) and leucovorin. Which of the following mechanisms accounts for the beneficial effects of leucovorin in this combination therapy for colorectal tumors?

A.Inhibition of thymidylate synthase
B.Inhibition of topoisomerase I
C.Potentiation of the efficacy of 5-FU
D.Rescue of cells exposed to 5-FU
E.Stimulation of natural killer cells
A

C.Potentiation of the efficacy of 5-FU

44
Q

A 55-year-old woman with diabetes undergoes kidney transplantation. Because she is receiving a graft from a heterologous donor, she must take immunosuppressive medications for life, which in her case is cyclosporine. Which of the following is the molecular target for cyclosporine as an immunosuppressive agent to prevent rejection of the allografted kidney in this patient?

A.Cyclophilin
B.Cytoplasmic receptors
C.Dihydroorotate dehydrogenase
D.Inosine monophosphate dehydrogenase
E.Interleukin-2 receptors
A

A.Cyclophilin

45
Q

A 10-year-old boy is irritable and complains of severe abdominal pain and headache. Physical examination shows evidence of muscle weakness, including wristdrop of the left hand. Laboratory studies show microcytic anemia with coarse basophilic stippling and an elevated level of free erythrocyte protoporphyrin. What is the most likely cause of this patient’s symptoms and what would be an appropriate treatment?

A.acetaminophen poisoning; treatment with acetylcysteine
B.arsenic poisoning; treatment with dimercaprol
C.iron poisoning; treatment with deferoxamine
D.lead poisoning; treatment with calcium disodium edetate
E.mercury poisoning; treatment with succimer

A

D.lead poisoning; treatment with calcium disodium edetate

46
Q

A 36-year-old man is brought to the emergency department by his friends. The man is confused and cannot remember the events of the past 2 days. His vision is blurry, and he has difficulty walking and keeping his balance. His friends report that he drinks alcohol on a daily basis. He started with two drinks a week 3 years ago, but has steadily increased and he now drinks ten 12-ounce cans of beer daily. Which of the following is the most appropriate pharmacotherapy for the patient?

A.Biotin
B.Folate
C.Niacin
D.Pyridoxine
E.Thiamine
A

E.Thiamine

47
Q

A 6-year-old boy with acute lymphocytic leukemia will begin remission induction therapy with a combination of vincristine, prednisone, and asparaginase. The therapeutic benefit of vincristine is attributed to its ability to

A.alkylate DNA, thereby causing DNA cross linkage and single-strand breakage
B.block thymidylate synthase, thereby preventing DNA synthesis
C.catalyze the hydrolysis of asparagine, thereby inhibiting protein synthesis
D.inhibit mitosis, thereby arresting cells in metaphase
E.intercalate with DNA, thereby preventing DNA and RNA synthesis

A

D.inhibit mitosis, thereby arresting cells in metaphase

48
Q 
Which of the following is a Polyfunctional alkylating agent used specifically for chronic myeloid leukemia:
A. cyclophosphamide
B. busulfan
C. thiopeta
D. dacarbazine
E. methotrexate
A

B. busulfan

49
Q 
Which of the following is used in combination with vinblastine and bleomycin: a major advance in treating nonseminomatous testicular cancer:
A. altretamine
B. cisplatin
C. procarbazine
D. methotrexate
E. cyclophosphamide
A

B. cisplatin

50
Q

A 53-year-old woman who is being treated for breast carcinoma complains of intense pain in her hips. A radiograph shows metastases in the pelvic bones, and laboratory findings include a serum calcium level of 13.2 mg/dL. Which of the following agents would be appropriate to give intravenously to lower this patient’s hypercalcemia?

A.PTH
B.Hydrochlorothiazide
C.Pamidronate
D.Raloxifene
E.Clomiphene
A

C.Pamidronate

51
Q

Colonic cancer is being treated with 5-fluorouracil as well as leucovorin (N5,N10-methylene tetrahydrofolate). The rationale for administering the coenzyme depends on it being essential for:

A. Conversion of 5-fluorouracil to fluorodeoxyuridylic acid.
B. Protection against the anemia caused by 5-fluorouracil treatment.
C. The inhibition of thymidylate synthase by fluorodeoxyuridylic acid.
D. Prolongation of the antitumor effect of 5-fluorourac.
E. All of the above

A

C. The inhibition of thymidylate synthase by fluorodeoxyuridylic acid.

52
Q

Which of the following drugs specifically inhibit calcineurin in the activated T lymphocytes?

A. Daclizumab.
B. Tacrolimus.
C. Prednisone.
D. Sirolimus.
E. Mycophenolate mofetil.
A

B. Tacrolimus.

53
Q

A 45-year-old male who received a renal transplant 3 months previously and is being maintained on prednisone, cyclosporine, and mycophenolate mofetil is found to have increased creatinine levels, and a kidney biopsy indicating severe rejection. Which of the following courses of therapy would be appropriate?

A. Increased dose of prednisone.
B. Hemodialysis.
C. Treatment with rabbit antithymocyte globulin.
D. Treatment with sirolimus.
E. Treatment with azathioprine.
A

C. Treatment with rabbit antithymocyte globulin.

54
Q

A 23-year-old female suffering from grand mal epilepsy is being controlled with phenytoin. She is a candidate for a renal transplant. Which agent might exacerbate the seizures in this patient?

A. Mycophenolate mofetil.
B. Sirolimus.
C. Cyclosporine.
D. Tacrolimus.
E. Prednisone
A

D. Tacrolimus.

55
Q

Which of the following drugs used to prevent allograft rejection can cause hyperlipidemia?

A. Azathioprine.
B. Basiliximab.
C. Tacrolimus.
D. Mycophenolate mofetil.
E. Sirolimus.
A

E. Sirolimus.

56
Q

Chronic ingestion of lead based paint chips will result in

A. Garlic breath
B. Changes in skin pigmentation
C. Accumulation of delta-ALA and inhibition of heme synthesis
D. Auditory & Visual loss
E. Interstitial Pneumonitis & Neurological effects

A

C. Accumulation of delta-ALA and inhibition of heme synthesis

57
Q

A 3 year old child brought to ER following the ingestion of several pills. The child is suffering from severe Gastro Intestinal discomfort and thrown up twice,each time producing a bloody vomitus. Questioning of mother reveals the child got into mother’s ols prenatal vitamins. What antidote should be given?

A. Dimercaprol
B. Deferroxamine
C. EDTA
D. Penicillamine
E. Succimer
A

B. Deferroxamine

58
Q

A patient is treated with Immunosuppressant drug following a liver transplant. The drug is known to bind to cyclophilin and inhibits the actions of calcineurin. For what drug toxicity should this patient be monitored?

A. Pulmonary fibrosis
B. Hypotension
C. Hypoglycemia
D. Nephrotoxicity
E. CHF
A

D. Nephrotoxicity

59
Q

Which one of the following agents has utility in the management of acute coronary syndromes such as Unstable angina?

A. Abciximab
B. Interferon-alpha
C. Aldesleukin
D. Filgrastim
E. Trastuzumab
A

A. Abciximab

60
Q

A patient undergoing cancer chemotherapy has an increase in urinary frequency with much discomfort. No specific findings are apparent on physical examination. Lab results include Hematuria and mild leukopenia,but no bacteria or crystalluria. If the symptoms experienced by the patient are drug related, what is the most likely cause?

A. Cyclophosphamide
B. 5-FU
C. Methotrexate
D. Prednisone
E. Tamoxifen
A

A. Cyclophosphamide

61
Q

Which of the following antidotes are specific competitive antagonists used in a clinical drug overdose?

A. Protamine sulphate  
B. Flumazenil 
C. Pralidoxime  
D. Acetylcysteine
E. Penicillamine
A

B. Flumazenil

62
Q

Which one of the following antidotes matches the underlying toxicity?

(A) Benzodiazepines — naloxone
(B) Narcotics — flumazenil
(C) Ethylene glycol — ethanol
(D) Acetaminophen — fomepizole 
(E) Aspirin— N-acetyl cysteine
A

(C) Ethylene glycol — ethanol

63
Q

A cancer patient is scheduled for “leucovorin rescue” soon after the administration of large doses of a chemotherapeutic agent. With which anticancer drug is this technique used?

A.Actinomycin D 
B.Bleomycin
C.Mercaptopurine
D.Methotrexate
E.Tamoxifen
F.Vincristine (or other vinca alkaloids)
A

D. Methotrexate

64
Q

A 12-year-old boy is poisoned when he drinks a solution that contains methanol. He is taken to the hospital, where he is given intravenous sodium bicarbonate and supportive therapy. Which of the following agents is considered an appropriate antidote to treat methanol poisoning in this patient?

A. Acetylcysteine
B. Atropine
C. Flumazenil
D. Disulfiram
E. Fomepizole
A

E. Fomepizole

65
Q

A 13-year-old boy is diagnosed with acute lymphocytic leukemia (ALL). He has thrombocytopenia and normocytic anemia, and his white blood cell count is 150,000/mm3. The patient begins treatment with vincristine and prednisone. Which vincristine-related adverse effect might occur in this patient?

A. Bladder toxicity
B. Cardiotoxicity
C. Nephrotoxicity
D. Neurotoxicity
E. Pulmonary toxicity
A

D. Neurotoxicity

66
Q

A 72-year-old woman with a long history of anxiety that has been treated with diazepam decides to triple her daily dose because of increasing fearfulness about “environmental noises.” Two days after her attempt at self-prescribing, she is found extremely lethargic and nonresponsive, with markedly obtunded reflexes and reaction to painful stimuli. Respirations are 8/min and shallow. Which of the following drugs should we give specifically to reverse these signs and symptoms?

A. Dextroamphetamine
B. Flumazenil
C. Naltrexone
D. Physostigmine
E. Pralidoxime
A

B. Flumazenil

67
Q

A patient with a recent drug poisoning is transported to the emergency department. The physician orders (correctly, in this case) administration of pralidoxime as part of the comprehensive emergency treatment plan. Which one of the following best describes who the patient was?

A. A 13-year-old boy who took an overdose of methylphenidate for his ADD/ADHD
B. A 43-year-old who took an overdose of neostigmine, prescribed for her myasthenia gravis, in a suicide attempt
C. A 6-year-old who got into the family medicine cabinet and took 10 “adult doses” of her dad’s prazosin
D. A farm/field worker accidentally doused with insecticide from an overflying crop-duster plane
E. An asthma patient who accidentally gave himself an intravenous injection of epinephrine in an attempt to self-treat a developing anaphylactic reaction

A

D. A farm/field worker accidentally doused with insecticide from an overflying crop-duster plane

68
Q

Which of the following is a drug that selectively inhibits the tyrosine kinase domain of the Bcr-Abl oncoprotein and is effective in chronic myelogenous leucemia?

A. anastrozole
B. fludarabine
C. imatinib
D. paclitaxel
E. trastuzumab
A

C. imatinib

69
Q

A 46-year-old woman with chronic alcoholism has recently undergone detoxification and has abstained from alcoholic beverages for several weeks. She has joined a “twelve-step” program and seeks assistance from her physician in helping maintain sobriety. Her physician prescribes an agent that is a structural analogue of γ-aminobutyric acid (GABA). By which mechanism does this agent help maintain abstinence from alcohol?

A. Accelerating ethanol catabolism
B. Augmenting dopaminergic activity in the nucleus accumbens
C. Blocking the effects of endorphins that reinforce the use of ethanol
D. Producing distressing symptoms when ethanol is ingested
E. Restoring the balance between excitatory and inhibitory neurotransmission

A

E. Restoring the balance between excitatory and inhibitory neurotransmission

70
Q

Your patient developed acute poisoning as a result of inhaling cyanide gas in an industrial accident. In addition to providing symptomatic, supportive care, and other appropriate interventions, administering which of the following would be the most likely to play a crucial role in treating the cyanide poisoning?

A. Ammonium chloride
B. Deferoxamine
C. Dimercaprol (BAL; British anti-Lewisite)
D. N-acetylcysteine
E. Pralidoxime
F. Sodium thiosulfate
A

F. Sodium thiosulfate

Pink Final (3 decks)

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