Anticancers

Question 1

Alkylating agents

Answer 1

nitrogen mustards,nitrosoureas,platinum compounds and others

Question 2

Antimetabolites

Answer 2

Folic acid analogues,purine analogues and pyrimidine analogues.

Question 3

cell cycle specific agents

Answer 3

antimetabolites,vinka alkaloids,texanes,epipdophyllotoxins &antibiotics

Question 4

cell cycle non specific

Answer 4

alkylating agents,anthracyclines,campothecins

Question 5

MOA of alkylating agents

Answer 5

cross link DNA at guanine nuclobases stopping replication.

Question 6

nitrogen mustards

Answer 6

cyclophosphamide,ifosfamide,chlorambucil.

Question 7

platinum compounds

Answer 7

carboplastin,cisplatin&oxaliplastin.

Question 8

nitrosoures

Answer 8

lomustine,carmustine,streptozocin.

Question 9

others

Answer 9

thiotepa,procarbazine

Question 10

Antifolates-Methotrexate

Answer 10

MOA:Binds to DHFR decreading nucleic acid synthesis.

Question 11

Pyrimidine analogues

Answer 11

FLUROURACIL(5-FU) MOA:inhibits DNA synthesis by inhibition of thymidylate synthetase.Can be incorporated into RNA to interfere with its processing

Question 12

Capecitabine

Answer 12

pirymidine analogue

Question 13

cytarabine

Answer 13

competitively inhibit DNA polymerase resulting in blockage of synthesis &repair

Question 14

Purine analogues

Answer 14

Azathioprine,6-TG,fludarabine,cladibrine and 6-MP

Question 15

6-MP

Answer 15

inhibits purine nucleotide synthesis

Question 16

Natural products

Answer 16

vinca alkaloids-vincristine,vinblastine,vinorelbine Texanes-Docetaxel,paclitaxel Epipodophylotoxins-etoposide,teniposide camptothecins-topotecan,irinotecan

Question 17

Vinca alkaloids

Answer 17

disrupt assembly of microtubules .Arrest cell growth at mitosis

Question 18

Texanes

Answer 18

arrest mitosis,

Question 19

epipodophyloyoxins

Answer 19

inhibit topoisomerase 2

Question 20

camptothecins

Answer 20

inhibits topoisomerase 1

Question 21

Antitumor antibiotics

Answer 21

anthracyclins-doxorubicin,idarubicin mitomycin C ,bleomycin &Actinomycin D MOA:cause DNA strand scission and interfere with cell proliferation.Bind to DNA through intercalation

Question 22

miscellenous

Answer 22

L-asparginase-depletes L-asparagine in tumor cells

Question 23

Tyrosine kinase inhibitors

Answer 23

imatinib,dasatinib

Question 24

Growtg factor receptor inhibitors

Answer 24

ceticimab,geftimib

Question 25

Hydroxyurea

Answer 25

inhibits ribonucleoside diphosphate reductase

Question 26

Tamoxifen

Answer 26

estrogen receptor blocker-inhibiting growth of breast cancer cells.FULVESTRANT

Question 27

Goserelin acetate

Answer 27

synthetic hormone that acts similarly ti GnRH resulting in decreased blood vessels of testosterinw and estrogen.RX for prostate and breast cancer.

Question 28

Immunomodulators

Answer 28

immunosuppressants and immunostimulants.

Question 29

Immunosuppressants

Answer 29

glucocorticoids;alkylating agebts,antimetabolites and drugs acting on immunophilins-cyclosporin&sirolimus

Question 30

immunostimulants

Answer 30

monoclonal antibodies-trastuzumab aldesleukin-interleukin

Question 31

angiogenesis inhibitors

Answer 31

thalidomide-caused phocomelia