Antifungals

Question 1

Amphotericin B

Answer 1

binds to ergosterol and alters the permeability of the cell membrane.has a broad spectrum of activity.it is a polyene.Other polyenes are nystatin and natamycin. DOC for acute systemic mycosis

Question 2

Flucytosine

Answer 2

MOA:it is taken up by cells via the enzyme cytosine permease .It is the converted to two compounds that inhibit DNA and RNA synthesis.it is active against C neoformans

Question 3

AZOLES

Answer 3

can be classified into imidazoles and triazoles

Question 4

imidazoles include

Answer 4

clotrimazole,ketoconazole and miconazole.

Question 5

triazoles include

Answer 5

itraconazole,fluconazole,voriconazole and posaconazole.

Question 6

MOA of azoles

Answer 6

reduce synthesis of ergosterol by inhibiting fungal CYP450 enzymes.

Question 7

ECHINOCANDINS

Answer 7

capsofungin,micafungin and anidulafungin.

Question 8

MOA

Answer 8

inhibit synthesis of beta 1-3 glucan resulting in the disruption of the fungal cell wall.

Question 9

Allylamines

Answer 9

terbinafine and naftifine.

Question 10

MOA o allylamines

Answer 10

inhibit ergosterol synthesis by blocking squalene epoxidase

Question 11

Griseofulvin

Answer 11

inhibits microtubule action.Used in the treatment of superficial mycoses

Question 12

thiocarbamates

Answer 12

tolnaftate.inhibits squalene epoxidase .

Question 13

Amorolfine

Answer 13

inhibits ergosterol synthesis.