Anticoagulants Flashcards
1
Q
what is the point of anticoagulants
A
reduce blood clots
2
Q
what are the 3 main classes of anticoagulants
A
- inhibitors of Factor Xa
- direct thrombin inhibitors
3, warfarin
3
Q
what are heparins
A
direct inhibitors of Factor Xa
4
Q
what does LMWH stand for
A
low molecular weight heparins
5
Q
2 types of heparin
A
UFH and LMWH
6
Q
where do heparins bind
A
antithrombin 111 and enhance antithrombin 111 binding to Factor Xa
7
Q
3 LMWHs
A
enoxaparin, dalteparin, tinzaparin
8
Q
what is the difference between LMWH and UFH
A
UFH also inhibits thrombin
9
Q
UFH are reversible via…
A
protamine sulfate
10
Q
hirudin peptide analogues
A
lepirudin
11
Q
what is lepirudin
A
direct thrombin inhibitor
12
Q
dabigatran
A
direct thrombin inhibitor
13
Q
therapeutic applications of anticoagulants
A
unstable angina prevention of STEMI prevention of stroke and TIA prevention of deep vein thrombosis bleeding
