Anticoagulants, Thrombolytics, & Antiplatelets Flashcards Preview

Pharm II Exam 4 > Anticoagulants, Thrombolytics, & Antiplatelets > Flashcards

Flashcards in Anticoagulants, Thrombolytics, & Antiplatelets Deck (21):
1

Platelet membrane receptors include....

Glycoprotein (GP) Ia receptor, binding to collagen (C)

GP Ib binding von Willebrand factor

GP IIb/IIIa binding fibrinogen & other macromolecules

2

During thrombus formation, what is released from the endothelium?

What is released form the degranulating platelet?

Antiplatelet prostacyclin (PGI2)

Aggregating substances - adenosine, diphosphate, thromboxane A2, & serotonin (5-HT)

3

What is the common synonym for component/factor II?

Prothrombin

4

What is the common synonym for component/factor VII?

Proconvertin

5

What is the common synonym for component/factor IX?

Plasma thromboplastin component (PTC)

6

What is the common synonym for component/factor X?

Stuart-Prower factor

7

What is the MOA of heparin & LMWH?

antithrombin w/ inactivation of factor Xa

8

What is the MOA of fondaparinux?

Indirect factor Xa inhibitor

9

What is the MOA of rivaroxaban, apixaban, & edoxaban?

Direct factor Xa inhibitors

10

What is the MOA of dabigatran, bivalirudein, desirudin, & argatroban?

Direct thrombin inhibitors

11

In patients w/ DVT or PE & no CA, what initial anticoagulant therapy is suggested?

Dabigatran, rivaroxaban, apixaban, or edoxaban

(These are preferred over vit K antagonist therapy)

12

What is the prototype of LMWH?

Enoxaparin (Lovenox)

13

What are the advantages of LMWH (when compared to UFH)?

Predictable anticoagulation dose response

Lower incidence of thrombocytopenia

Reduced need for lab monitoring

14

What is a disadvantage of both LMWH & UFH?

Bleeding risk: ecchymosis at administration site

15

What is the 1/2 life of factor VII?

4-6 hrs

16

What do you do if INR is btwn 5-10?

Hold 1-2 doses

Check INR within 24 hrs

Resume lower dose when INR is within range

17

What do you do if INR is > 10?

Administer oral vit K 2.5-5mg

Hold 2 doses

Check INR within 24 hrs

Repeat vit K prn & resume lower dose when INR is in range

18

How do you convert from enoxaparin to warfarin?

Warfarin must be on board for 5 days & INR score must be within goal range for at least 24 hrs before discontinuing enoxaparin

19

What are ADEs of heparin?

Bleeding, obvi
Thrombocytopenia
Osteoporosis
Elevated transaminases

20

How do you reverse heparin?

Protamine sulfate IV (salmon sperm)

21

What increases & decreases the effect of warfarin?

Cytochrome P450 inducing drugs decrease effect

Cytochrome P450 inhibitions increase effect