Anticonvulsants

Question 1

GABA neurotrans roll in seizures?

Answer 1

GABAergic neuron activity controls seizures

Question 2

Glutamate neurotrans roll in seizures?

Answer 2

Increase in Glutamate activity causes seizures

Question 3

Sodium channels roll in seizures?

Answer 3

Open Na+ channels propagate APs

Rapid firing of Na+ channels leads to seizures

Question 4

Calcium channels roll in seizures?

Answer 4

Absence seizures from overactive Ca+2 channels in thalamus

Question 5

Drugs that increase GABA activity and decrease seizures?

Answer 5

Phenobarbital

BZs

Question 6

Drugs that inhibit Glutamate transmission and decrease seizures?

Answer 6

Phenytoin/Dilantin
Carbamazepine
Lamotrigine
Valporic acid
Ethosuximide

Question 7

Phenytoin/Dilantin inhibits metabolism of what drug?

Increases metabolism of what drugs?

What med increases metabolism of phenytoin?

Answer 7

Warfarin

OCP

Carbamazepine

Question 8

Phenytoin/Dilantin s/e?

Answer 8

Gingival hyperplasia
Hirsuitism
Abn Vit D/Ca+2 absorb
Periph neuropathy

Question 9

Carbamazepine/Tegretol uses?

Answer 9

Seizures
Bipolar
Trigem neuralgia

Question 10

Carbamazepine/Tegretol s/e?

Answer 10

Diplopia
Ataxia
GI
AGRANULOCYTOSIS

Question 11

Carbamazepine/Tegretol increases metabolism of what drugs?

What meds inhibit metabolism of Carbamazepine?

Answer 11

Phenytoin, valproic acid, OCP

Cimetidine, fluoxetine, EMC

Question 12

Lamotrigine uses?

S/e?

Answer 12

Absence
Bipolar

Steven-johnson
Dizzy
HA
N
Somnolence

Question 13

Gabapentin uses?

S/e?

Answer 13

Adjunct seizures
Neuropathic pain

Dizzy
Drowsy
Ataxia
Wgt gain
No preggos

Question 14

Topiramate/Topamax s/e?

Answer 14

Dizzy
Sedation
Confusion
No preggos

Question 15

Valproic Acid/Depakote uses?

S/e?

Answer 15

Seizures
Bipolar

N/V
Tremor
Wgt gain
Hepatotoxicity
Steve-John