Antidepressants

Question 0

Desipramine

Answer 0

TCA- 2ary amine (less sedation/antichol, more NE)

Question 1

Imipramine

Answer 1

TCA -3ary amine (inc sedation, inc 5HT, inc anticholinergic)

For enuresis

Question 2

Amitriptyline

Answer 2

TCA- 3ary amine (more sedation)

Question 3

Nortriptyline

Answer 3

TCA - 2ary amine

Least cardiac effects

Question 4

Timipramine

Answer 4

TCA- 3ary amine

Question 5

Doxepine

Answer 5

TCA- 3ary amine

Question 6

Clomipramine

Answer 6

TCA - 3ary amine

For OCD

Question 7

Protriptyline

Answer 7

TCA- 2ary amine

Question 8

Phenelzine

Answer 8

MAOI

Question 9

Tranylcypromine

Answer 9

MAOI

Question 10

Fluoxetine

Answer 10

SSRI - Prozac
LONG T1/2 (4wks to reach ss, 5wks to get rid off)
Inhibits CYP2D6- interactions w/ TCA, warfarin, phenytoin/carbamazepine, bb, opoids, tamoxifen, tramadol (seizures)

Question 11

Fluvoxamine

Answer 11

SSRI

Question 12

Paroxetine

Answer 12

SSRI + OCD and social anxiety
Inhibits CYP2D6 - DI w/ TCA, warfarin, phenytoin/carbamazepine, BB, opoids.
Some sedation, GI side effects. NOT safe in pregnancy

Question 13

Sertaline

Answer 13

SSRI

Similar to Fluoxetine, less DI, shorter T1/2

Question 14

Citalopram

Answer 14

SSRI
-Fewer side effects and DI
useful in hot flashes

Question 15

Escitalopram

Answer 15

SSRI - fastest onset
Fewer side effects and DI
Useful in hot flashes

Question 16

Venlafaxine

Answer 16

SNRI - for chronic pain
Inhibits reuptake of 5HT & NE
Inc BP

Question 17

Desvenlafaxine

Answer 17

SNRI

Question 18

Duloxetine

Answer 18

SNRI - depression associated pain

Inc liver enzymes, some CYP2D6 inhibition

Question 19

Milnacipram

Answer 19

SNRI - fibromyalgia

Induces liver enzymes

Question 20

Levomilnacipram

Answer 20

SNRI

Question 21

Bupropion

Answer 21

Anti-depressant - inhibits DA reuptake
Smoking cessation (ext release), alcoholism, night eating, ADHD
FEWER SEXUAL SIDE EFFECTS, can give anxiety
CI: seizures or head trauma

Question 22

Mirtazapine

Answer 22

Anti-depressant - blocks presynaptic a2, blocks 5HT2a & 5HT3
no cardiac toxicity
sedation (antihistamine), wt gain

Question 23

Atomoxetine

Answer 23

Anti-depressant - blocks NE reuptake
ADHD med for <6yo
CI w/ vasopressors (epi, ne) and MAOIs
GI pd, hepatotoxicity

Question 25

Maprotiline

Answer 25

Anti-depressant - blocks NE reuptake | cardiac effects, seizures

Question 27

Amoxapine

Answer 27

Anti-depressant - blocks NE (&5HT) reuptake, blocks DA receptor Some antipsychotic effect, sedation

Question 27

Traxodone

Answer 27

Anti-depressant (not very good) - partial agonist at 5HT1a, blocks 5HT2a For pain management and insomnia sedation, PRIAPISM

Question 27

St Johns Wort

Answer 27

Anti-depressant - effective for mild depression | Photosensitivity, don't combine w/ other antidepressants, harder to get out of anesthesia

Question 28

HTN crisis

Answer 28

When combine MAOIs w/ tyramine (wine/cheese) or sympathomimetics (cold meds) or Buspirone. Tx w/ phentolamine (a-blocker)

Question 29

Serotonin syndrome

Answer 29

Hyperpyrexia, convulsions, twitches, delirium If combine MAOIs w/ TCAs, SSRIs, Meperedine, or Dextromethorphan If combine SSRIs w/ MAOIs, St John's wort, amphetamines. Tx w/ benzos

Question 30

SSRIs

Answer 30

DOC for depression, panic disorder, OCD Also used in social anx, bulimia, PMDD, alcoholism, premature ejac No memory impairement- can use in children/adolescent/elderly Side effects: GI, photosensitivity, wt gain (chronic)

Question 31

Selegeline

Answer 31

MAOI, selective for MAO-B (breaks down DA)

Question 32

Vortioxetine

Answer 32

SSRIs + agonist at 5HT1a- anxiolytic

Question 33

Viladozone

Answer 33

SSRI + agonist at 5HT1a - anxiolytic